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ALE-0540
(ALE0540) manufacturers
- ALE-0540
-
- $35.00
-
2026-04-22
- CAS:234779-34-1
- Purity: 99.88%
- Supply Ability: 10g
|
| | ALE-0540
(ALE0540) Basic information |
| Product Name: | ALE-0540
(ALE0540) | | Synonyms: | ALE-0540
(ALE0540);1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[(2-hydroxyethyl)amino]-5-nitro-;2-[(2-hydroxyethyl)amino]-5-nitro-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione;2-((2-Hydroxyethyl)amino)-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione;ALE-0540, 10 mM in DMSO;ALE-0540 | | CAS: | 234779-34-1 | | MF: | C14H11N3O5 | | MW: | 301.25 | | EINECS: | | | Product Categories: | | | Mol File: | 234779-34-1.mol |  |
| | ALE-0540
(ALE0540) Chemical Properties |
| Boiling point | 584.9±60.0 °C(Predicted) | | density | 1.60±0.1 g/cm3(Predicted) | | pka | 14.49±0.10(Predicted) | | form | Beige solid. | | color | Light yellow to yellow |
| | ALE-0540
(ALE0540) Usage And Synthesis |
| Uses | ALE-0540, a nonpeptidic small molecule, is a nerve growth factor receptor antagonist. ALE-0540 inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA with IC50 values of 5.88 μM and 3.72 μM, respectively. ALE-0540 can be used to examine mechanisms leading to the development of agents for the treatment of pain[1]. | | References | [1] Owolabi JB, et al. Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat. J Pharmacol Exp Ther. 1999 Jun;289(3):1271-6. PMID:10336516 |
| | ALE-0540
(ALE0540) Preparation Products And Raw materials |
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