Bobcat339 (Bobcat 339)

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: CAS:2280037-51-4
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
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CAS:2280037-51-4
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Products Intro: Product Name:Bobcat339 (Bobcat 339)
CAS:2280037-51-4
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Company Name: Zhejiang J&C Biological Technology Co.,Limited
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CAS:2280037-51-4
Purity:99% Package:5KG;1KG Remarks:Bobcat339
Company Name: CR Corporation Limited
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Products Intro: Product Name:Bobcat339
CAS:2280037-51-4

Bobcat339 (Bobcat 339) manufacturers

  • Bobcat339
  • Bobcat339 pictures
  • $47.00 / 5mg
  • 2026-05-11
  • CAS:2280037-51-4
  • Min. Order:
  • Purity: 98.62%
  • Supply Ability: 10g
  • Bobcat 339
  • Bobcat 339 pictures
  • $3.44 / 1KG
  • 2022-03-31
  • CAS:2280037-51-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10kg
  • Bobcat 339
  • Bobcat 339 pictures
  • $3.44 / 1KG
  • 2022-02-25
  • CAS:2280037-51-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100KG
Bobcat339 (Bobcat 339) Basic information
Product Name:Bobcat339 (Bobcat 339)
Synonyms:Bobcat339 (Bobcat 339);Bobcat399;2(1H)-Pyrimidinone, 4-amino-1-[1,1'-biphenyl]-3-yl-5-chloro-;1-([1,1'-Biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one;enzyme,Inhibitor,Cytosine-based,TET,Bobcat 339,inhibit,Bobcat339,DNA Methyltransferase,DNA MTases,DNMTs,epigenetics,Bobcat-339,TET1,TET2;4-amino-1-{[1,1'-biphenyl]-3-yl}-5-chloro-1,2-dihydropyrimidin-2-one;Bobcat339, 10 mM in DMSO
CAS:2280037-51-4
MF:C16H12ClN3O
MW:297.74
EINECS:604-604-1
Product Categories:
Mol File:2280037-51-4.mol
Bobcat339 (Bobcat 339) Structure
Bobcat339 (Bobcat 339) Chemical Properties
Boiling point 489.0±55.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 1 mg/ml,DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:8): 0.11 mg/ml
form A crystalline solid
pka2.42±0.10(Predicted)
color Off-white to light yellow
InChI1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21)
InChIKeyQMGYGOOYCNTEQO-UHFFFAOYSA-N
SMILESNC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
Bobcat339 (Bobcat 339) Usage And Synthesis
UsesBobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].
Biological ActivityBobcat339 is a cell penetrant, potent and selective inhibitor of TET1 and TET2 [Ten-eleven translocation methylcytosine dioxygenase (TET) 1 and 2] th at reduces content of 5-hydroxymethyl-cytosine (5hmC) in cultured neurons. Bobcat339 does not inhibit DNMT3a.
IC 50TET1: 33 μM (IC50); TET2: 73 μM (IC50)
storageStore at -20°C
References[1] Chua GNL, et, al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31; 10(2): 180-185. DOI:10.1021/acsmedchemlett.8b00474
[2] Weirath NA, et al. Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper(II). ACS Med Chem Lett. 2022 Apr 21;13(5):792-798. DOI:10.1021/acsmedchemlett.1c00677
Bobcat339 (Bobcat 339) Preparation Products And Raw materials
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