Methyltetrazine-PEG8-acid manufacturers
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| | Methyltetrazine-PEG8-acid Basic information |
| Product Name: | Methyltetrazine-PEG8-acid | | Synonyms: | Methyltetrazine-PEG8-acid;Propanoic acid, 3-[[23-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]oxy]-;3-[2-[2-[2-[2-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid;Methyltetrazine-PEG8-COOH;1-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid;Methyltetrazine-O-PEG9-acid;Methyltetrazine-PEG9-COOH | | CAS: | 2183440-33-5 | | MF: | C28H44N4O11 | | MW: | 612.67 | | EINECS: | | | Product Categories: | | | Mol File: | 2183440-33-5.mol |  |
| | Methyltetrazine-PEG8-acid Chemical Properties |
| solubility | Soluble in Water, DMSO, DCM, DMF | | form | Solid | | color | Purple to purplish red |
| | Methyltetrazine-PEG8-acid Usage And Synthesis |
| Description | Methyltetrazine-PEG8-Acid is a click chemistry building block. In the presence of activators (e.g. EDC, or HATU), it can be used to conjugate with amine-containing molecule. PEG8 spacer increases the aqueous solubility of the compound. Methyltetrazine enable fast click chemistry with TCO ((trans-cycloctene) under mild condition | | Uses | Methyltetrazine-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Methyltetrazine-PEG8-acid Preparation Products And Raw materials |
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