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Hyaluronidase

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CAS:37326-33-3
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Products Intro: Product Name:Recombinant Human Hyaluronidase PH20
CAS:37326-33-3
Purity:greater than 99% Package:ampule of 300 × units Remarks:Recombinant Human Hyaluronidase (PH20) belongs to a family of enzymes that catalyze the degradation of hyaluronic acid and can degrade hyaluronic acid in the extracellular matrix and promote the diffu

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Hyaluronidase Basic information
Product Name:Hyaluronidase
Synonyms:Hyaluronidase - CAS 37326-33-3 - Calbiochem;HYALURONATE GLYCANOHYDROLASE;HYALURONIDASE BOVINE TESTES;HYALURONIDASE OVINE TESTES;HYALURONIDASE, SALT-FREE, BOVINE;HYALURONIDASE, STREPTOMYCES HYALURONLYTICUS NOV SPECIES;HYALURONIDASE TYPE II;HYALURONIDASE TYPE III
CAS:37326-33-3
MF:NULL
MW:0
EINECS:253-464-3
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Mol File:Mol File
Hyaluronidase Structure
Hyaluronidase Chemical Properties
storage temp. -20°C
solubility Soluble in water, practically insoluble in acetone and in anhydrous ethanol
form powder
color yellow-brown
biological sourcesheep testis
Water Solubility 0.5 M acetate, pH 6.0: 30U/mL
water: 30U/mL
Specific Activity750-3000units/mg solid
Safety Information
Safety Statements 22-24/25
WGK Germany 3
3-10
HS Code 35079090
MSDS Information
ProviderLanguage
SigmaAldrich English
Hyaluronidase Usage And Synthesis
Chemical PropertiesWhite or yellowish-white, amorphous powder.
UsesUsed to promote absorption of fluid into tissues.
UsesHyaluronidase from sheep testes has been used:
  • in flow cytometry
  • in the isolation of putative spermatogonial stem cells (SSCs)
  • to study the effects of magnetic stimulation in magnetic hydrogel properties
  • in immunohistochemistry to visualize collagen type II distribution
  • to expose group-III auditory neurons of Muller′s organ for patch-clamp recordings
  • for the degeneration of hydrogels

DefinitionAny of a class of soluble enzymes produced in mammalian testes that catalyze cleavage of glycosidic bonds of oartucular mucopolysaccharides. As a component of venoms, it reduces the viscosity of connective tissues and promotes tissue penetration of the ve
General DescriptionHyaluronidase is a hyaluronic acid-metabolizing enzyme. It is found in the venoms of snake, honeybee and hymenoptera. Hyaluronidase degrades hyaluronic acid (HA), which enhances membrane permeability, lowers viscosity and increases tissue permeability. It enhances the diffusion of local anesthetics, lowers the size of myocardial infarction, improves the effects of anticancer drugs and prevents perineal trauma during spontaneous delivery.
Biochem/physiol ActionsHyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression.
Purification MethodsHyaluronidase is purified by chromatography on DEAE-cellulose prior to use. [Distler & Jourdain J Biol Chem 248 6772 1973.]
Hyaluronidase Preparation Products And Raw materials
Raw materialsAmmonium sulfate
Tag:Hyaluronidase(37326-33-3) Related Product Information
Sodium hyaluronate Recombinant Ribokinase from E. coli Recombinant Ketol-acid reductoisomerase from Mycobacterium tuberculosis Recombinant Adenosine deaminase from Pseudomonas aeruginosa Recombinant Herpes simplex virus (HSV-1) thymidine kinase Recombinant Ribosomal-protein-serine acetyltransferase from E. coli Recombinant Adenine phosphoribosyltransferase from E. coli Nucleoside phosphorylase Recombinant Ribose-phosphate pyrophosphokinase from E. coli Hyaluronic Acid from Bovine Vitreous Humor [Substrate for Hyaluronidase] SALCOMINE COBALT(II) ACETYLACETONATE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ethyl isocyanoacetate Benzyl isocyanide

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