| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Company Name: |
Upstate |
| Tel: |
434 975 4300 |
| Email: |
info@upstate.com |
|
| | ANTI-P300 Basic information |
| Product Name: | ANTI-P300 | | Synonyms: | P300 (AB-1) MONOCLONAL ANTIBODY;Monoclonal Anti-EP300 antibody produced in mouse;ANTI-HUMAN P300;ANTI-P300 CT;ANTI-P300, HUMAN;ANTI-P300 MOUSE MAB;ANTI-P300;ANTI-P300(AB-1) | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-P300 Structure]() |
| | ANTI-P300 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | mouse |
| Storage Class | 10 - Combustible liquids |
| | ANTI-P300 Usage And Synthesis |
| Uses | This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. (provided by RefSeq) | | Biological Activity | E1A binding protein p300 (p300) and CBP (CREB binding protein) are highly related transcriptional coactivators. Both proteins have been identified through protein interaction assays. In addition to interacting with a variety of cellular factors and oncoproteins, loss of the wild type CBP alleles in isolated tumors suggests th at CBP/p300 might serve as tumor suppressors. The ability of p300 to acetylate many transcription factors, including tumor suppressor p53, E2 factor (E2F), transcription factors II E and -F (TFIIE and -F) etc. demonstrates a novel mechanism of targeted p300 regulation of gene expression. Mutations in the gene encoding the protein have been linked to Rubinstein-Taybi syndrome (RSTS). |
| | ANTI-P300 Preparation Products And Raw materials |
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