| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:5-CarboxaMidotryptaMine Maleate
CAS:74885-09-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Basic information |
| | 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Chemical Properties |
| Boiling point | 513.6±35.0 °C(Predicted) | | density | 1.293±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | H2O: 10 mg/mL | | form | solid | | pka | 16.32±0.30(Predicted) | | color | white or off-white | | Stability: | Hygroscopic |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Usage And Synthesis |
| Uses | 5-Carboxamidotryptamine maleate is an agonist of the 5-HT1 receptors. | | Definition | ChEBI: 5-carboxamidotryptamine is a member of tryptamines. | | in vivo | 5-Carboxamidotryptamine (0.03-3 mg/kg i.p. and 0.125-5 μg i.c.v.) causes a dose-dependent reduction in rectal temperature of mice[3].
5-Carboxamidotryptamine (0.1-1 mg/kg; i.p.) reduces rectal temperature in wild type mice but not 5-HT7 receptor knockout mice[3].
5-Carboxamidotryptamine (0.0 1-1 μg/kg; i.v.) causes consistent, dose-related decreases in diastolic blood pressure and carotid arterial vascular resistance and increases in heart rate of cats. In contrast, 5-HT (1-100 μg/kg; i.v.) causes tachycardia but variable and complex effects on diastolic blood pressure and carotid arterial vascular resistance[5].
5-Carboxamidotryptamine does not cause bronchoconstriction in cats. In contrast, 5-HT causes dose-related bronchoconstriction[5]. | Animal Model: | Male Swiss Webster mice (20-25 g)[3] | | Dosage: | 0.03-3 mg/kg (i.p.) and 0.125-5 μg (i.c.v.) | | Administration: | i.p. and i.c.v. | | Result: | Caused dose-dependent reduction in rectal temperature. |
| Animal Model: | 5-HT7 receptor knockout mice (background=50% 129SvEv/50% C57Bl/6J)[3] | | Dosage: | 0.1-1 mg/kg | | Administration: | i.p. and i.c.v. | | Result: | Reduced rectal temperature in wild type but not 5-HT7 receptor knockout mice. |
| | IC 50 | 5-HT1A Receptor; 5-HT1B Receptor; 5-HT1D Receptor; 5-HT5A Receptor; 5-HT7 Receptor |
| | 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Preparation Products And Raw materials |
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