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| | 5-Amino-2-benzimidazolethiol Basic information | | Uses |
| | 5-Amino-2-benzimidazolethiol Chemical Properties |
| Melting point | 240-244 °C (lit.) | | Boiling point | 356.8±44.0 °C(Predicted) | | density | 1.2404 (rough estimate) | | refractive index | 1.5605 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | form | powder to crystal | | pka | 10.44±0.30(Predicted) | | color | Light yellow to Amber to Dark green | | Stability: | Stable under recommended storage conditions., Stable Under Recommended Storage C | | InChI | InChI=1S/C7H7N3S/c8-4-1-2-5-6(3-4)10-7(11)9-5/h1-3H,8H2,(H2,9,10,11) | | InChIKey | BXDMTLVCACMNJO-UHFFFAOYSA-N | | SMILES | C1(=S)NC2=CC=C(N)C=C2N1 | | CAS DataBase Reference | 2818-66-8(CAS DataBase Reference) | | EPA Substance Registry System | 2H-Benzimidazole-2-thione, 5-amino-1,3-dihydro- (2818-66-8) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5-Amino-2-benzimidazolethiol Usage And Synthesis |
| Uses | Compounds with a benzimidazole structure, led by omeprazole, can inhibit the acid secretion of gastric parietal cells induced by any stimulus, thus inhibiting the final step of gastric acid being pumped from the parietal cells into the gastric lumen, and therefore have the best therapeutic effect. 5-Amino-2-mercaptobenzimidazole, as an important starting material or intermediate for this type of drug, has a huge market demand. | | Chemical Properties | off-white to light yellow crystalline powder | | Synthesis | Dissolve 2-mercapto-5-nitrobenzimidazole in methanol, ethanol, dichloromethane, trichloromethane or tetrahydrofuran and add 5-20 equivalents of zinc powder in batches. Concentrated hydrochloric acid is slowly added to the mixture until said mixture is colorless. At the end of the reaction, the insoluble material is removed by filtration, and the filtrate is adjusted to pH=9-10 by adding saturated potassium carbonate solution. activated carbon is added to decolorize the reaction, and the reaction continues to be heated and refluxed for 0.5-2 h. The reaction is filtered through diatomaceous earth, and dried to obtain a yellow solid of 5-amino-2-mercaptobenzimidazole. |
| | 5-Amino-2-benzimidazolethiol Preparation Products And Raw materials |
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