|
|
| | SC-68376 Basic information |
| | SC-68376 Chemical Properties |
| Boiling point | 352.3±27.0 °C(Predicted) | | density | 1.149±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 18 mg/mL | | form | solid | | pka | 3.19±0.10(Predicted) | | color | off-white |
| | SC-68376 Usage And Synthesis |
| Uses | SC-68376 is a potent, reversible, ATP-competitive, and selective inhibitor of p38 MAP kinase inhibitor[1][2][3]. | | Definition | ChEBI: 2-methyl-4-phenyl-5-pyridin-4-yloxazole is a member of 1,3-oxazoles. | | References | [1] H. Bosch, et al. Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors. US20030181411A1. 2005-12-07.
[2] Ermert M, et al. Cyclooxygenase-2-dependent and thromboxane-dependent vascular and bronchial responses are regulated via p38 mitogen-activated protein kinase in control and endotoxin-primed rat lungs. Lab Invest. 2003;83(3):333-347. DOI:10.1097/01.lab.0000059924.47118.88
[3] Kooijman R, et al. IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase. Cell Signal. 2003;15(12):1091-1098. DOI:10.1016/s0898-6568(03)00069-x |
| | SC-68376 Preparation Products And Raw materials |
|