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Sigma-Aldrich |
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021-61415566 800-8193336 |
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GW8510 manufacturers
- GW8510
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- $538.00
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2026-07-27
- CAS:222036-17-1
- Purity: 99.32%
- Supply Ability: 10g
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| Product Name: | GW8510 | | Synonyms: | GW-8510
(GW8510;4-{[(7-oxo-6,7-dihydro-8h-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-n-(2-pyridyl)benzenesulfonamide;Benzenesulfonamide, 4-[[(6,7-dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinyl-;4-(((7-Oxo-6,7-dihydro-8H-thiazolo[5,4-e]indol-8-ylidene)methyl)amino)-N-(pyridin-2-yl)benzenesulfonamide | | CAS: | 222036-17-1 | | MF: | C21H15N5O3S2 | | MW: | 449.51 | | EINECS: | | | Product Categories: | | | Mol File: | 222036-17-1.mol |  |
| | GW8510 Chemical Properties |
| density | 1.635±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: soluble | | form | solid | | pka | 8.39±0.10(Predicted) | | color | Light yellow to yellow | | InChI | InChI=1S/C21H15N5O3S2/c27-21-15(19-16(25-21)8-9-17-20(19)30-12-24-17)11-23-13-4-6-14(7-5-13)31(28,29)26-18-3-1-2-10-22-18/h1-12,23H,(H,22,26)(H,25,27) | | InChIKey | GCYXEGSPUDSZJY-UHFFFAOYSA-N | | SMILES | C1(S(NC2=NC=CC=C2)(=O)=O)=CC=C(NC=C2C3=C4SC=NC4=CC=C3NC2=O)C=C1 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | GW8510 Usage And Synthesis |
| Uses | GW8510 is a potent cyclin-dependent kinase-2 (CDK2) inhibitor. GW8510 is also a ribonucleotide reductase M2 (RRM2) inhibitor. GW8510 exhibits neuroprotective and anticancer activities[1][2][3]. | | Definition | ChEBI: 4-[(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methylamino]-N-(2-pyridinyl)benzenesulfonamide is a sulfonamide and a member of benzenes. | | Biochem/physiol Actions | Initially characterized as an inhibitor of cyclin-dependent kinase 2 (CDK2), subsequent research has shown GW8510 to be non-selective. | | in vivo | Combination with GW8510 and Tamoxifen enhances tumoricidal effect on Tamoxifen-resistant BBC xenograft through autophagy induction[3]. | | IC 50 | CDK2; CDK5; RRM2 | | References | [1] ARCAMONE F, et, al. STRUCTURE AND SYNTHESIS OF DISTAMYCIN A. Nature. 1964 Sep 5;203:1064-5. DOI:10.1038/2031064a0
[2] Hiraku Y, et, al. Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis. Nucleic Acids Res Suppl. 2002;(2):95-6. DOI:10.1093/nass/2.1.95
[3] Majumder P, et, al. Effect of DNA groove binder distamycin A upon chromatin structure. PLoS One. 2011;6(10):e26486. DOI:10.1371/journal.pone.0026486 |
| | GW8510 Preparation Products And Raw materials |
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