2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDRO- manufacturers
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| | 2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDRO- Basic information |
| | 2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDRO- Chemical Properties |
| Melting point | 264 °C (dec.)(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | form | solid | | Appearance | Off-white to light brown Solid | | BRN | 3698942 | | InChI | InChI=1S/C8H9N3.2ClH.H2O/c9-5-8-10-6-3-1-2-4-7(6)11-8;;;/h1-4H,5,9H2,(H,10,11);2*1H;1H2 | | InChIKey | HAEYZZSSSUIZAN-UHFFFAOYSA-N | | SMILES | C12C=CC=CC=1N=C(CN)N2.O.Cl.Cl |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDRO- Usage And Synthesis |
| Chemical Properties | off-white to green-greyish powder | | Uses | 2-(Aminomethyl)benzimidazole dihydrochloride was used in the synthesis of N-(benzimidazol-2-ylmethyl)iminodiacetic acid. | | Synthesis | A) Take o-phenylenediamine, glycine and 5~6mol/L HCl, sequentially added to the flask, in which the molar ratio of o-phenylenediamine and glycine is 1:1-3, 1:1.5-2.5; the molar ratio of o-phenylenediamine and 5~6mol/LHCl is 1:10-12. stirred uniformly, put into the microwave oven of the frequency of 2450MHz at an output power of 119W and irradiated intermittently for 6 times, 1min each time, to make the total solution. B) the whole solution in the microwave oven at an output power of 119 ~ 280W intermittent irradiation 10 times, each time the irradiation of 4 ~ 6min after an interval of 10min. cooling, precipitation of solids, filtration, anhydrous ethanol washed, drying to obtain the crude product. C)The crude product was recrystallized with anhydrous ethanol to obtain 2-aminomethylbenzimidazole dihydrochloride, which was dissolved in water, adjusted pH to 8~9 with ammonia, cooled to 3~5 to make the crystallization complete, and recrystallized with ethanol/water to obtain 2-aminomethylbenzimidazole, with a maximum yield of 77%. 2-aminomethylbenzimidazole further reacted with hydrochloric acid to form 2-(aminomethyl)benzimidazole dihydrochloride |
| | 2-(AMINOMETHYL)BENZIMIDAZOLE DIHYDRO- Preparation Products And Raw materials |
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