化合物 T28615
| 中文名称 | 化合物 T28615 |
|---|---|
| 中文同义词 | 化合物 T28615;化合物 SP-CAMPS;(S)-腺苷环3',5'-(硫代磷酸氢根)三乙铵 |
| 英文名称 | ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE |
| 英文同义词 | adenosine-3’,5’-cyclicmonophosphorothioate,sp-isomer(sp-camps),sodiumsalt;camps,sp-isomer,teasalt;ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE;(S)-Adenosine;cAMPS-Sp;Triethylammoniumsalt;(S)-ADENOSINE, CYCLIC 3',5'-(HYDROGENPHOSPHOROTHIOATE) TRIETHYLAMMONIUM;ADENOSINE3,5-CYCLICMONOPHOSPHOTHIOATESP-ISOMERTRIETHYLAMMONIUMSALT,HIGHPURITY |
| CAS号 | 71774-13-5 |
| 分子式 | C10H12N5O5PS |
| 分子量 | 345.27 |
| EINECS号 | |
| 相关类别 | Cyclic Nucleotide related |
| Mol文件 | 71774-13-5.mol |
| 结构式 |  |
化合物 T28615 性质
| 沸点 | 648.0±65.0 °C(predicted) |
|---|---|
| 密度 | 2.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) |
| 储存条件 | Desiccate at -20°C |
| 溶解度 | water: 20 mg/mL |
| 形态 | crystalline solid |
| 酸度系数(pKa) | -0.55±0.60(predicted) |
| 水溶解性 | water: 20mg/mL |
Sp-cAMPS，一种 cAMP 类似物，是一种依赖 cAMP 的 PKA I 和 PKA II 的有效激活剂。Sp-cAMPS 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 µM。Sp-cAMPS 以 EC50 为 40 μM 来结合 PDE10 GAF 域。
|
PKA I
|
PKA II
|
PDE3A 47.6 μM (Ki) |
PDE10 GAF domain 50 μM (EC 50 ) |
Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca 2+ can be mimicked by Sp-cAMPS.
In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals.
安全信息
| WGK Germany | WGK 2 |
|---|---|
| 存储类别 | 11 - 可燃固体 |