5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester

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5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester Suppliers list
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Company Name: Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd  
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Email: et@chemextension.com

5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester manufacturers
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester Basic information
Product Name:5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester
Synonyms:5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester
CAS:2252422-32-3
MF:C26H38N2O10
MW:538.59
EINECS:
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Mol File:2252422-32-3.mol
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester Structure
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester Chemical Properties
density 1.28±0.1 g/cm3(Predicted)
storage temp. Storage temp. -20°C
solubility Soluble in DMSO, DCM, DMF
pka12.05±0.46(Predicted)
form Liquid
color Colorless to light yellow
Safety Information
MSDS Information
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester Usage And Synthesis
Descriptionendo-BCN-PEG4-NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The BCN group enables copper free click chemistry with azide-tagged biomolecules. The hydrophilic PEG spacer increases solubility in aqueous media.
Usesendo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester Preparation Products And Raw materials
Tag:5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester(2252422-32-3) Related Product Information
Exo-bcn-PEG4-NHS ester endo-BCN-PEG8-NHS ester endo-BCN-PEG2-NHS ester Endo BCN-PEG3-NHS Ester endo-BCN-PEG12-NHS ester endo-BCN-PEG12-NHS ester