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| | CD38 Antibody Chemical Properties |
| | CD38 Antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | Cyclic ADP-ribose hydrolase 1 is a transmembrane protein involved in several important biological processes, including immune response, insulin secretion, and social behavior. Originally described as a glycosylated immune cell surface marker, additional research determined that CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP ribose from NAD. Under acidic conditions, CD38 also catalyzes the synthesis of nicotinic acid adenine dinucleotide phosphate from NADP+. Both cADPR and NAADP act as calcium ion mobilizing messengers that target different intracellular Ca2+ stores. Since CD38 is the primary mammalian NAD+ glycohydrolase responsible for NAD+ metabolism, CD38 may be a valuable therapeutic target for treatment of metabolic diseases regulated by NAD+-dependent pathways. CD38 has also been considered a possible therapeutic target for antibody-mediated therapy for myeloma and chronic lymphocytic leukemia. | | References | [1] Malavasi, F. et al. (2008) Physiol Rev 88, 841-86.
[2] Jin, D. et al. (2007) Nature 446, 41-5.
[3] Lee, H.C. et al. (1999) Mol Cell Biochem 193, 89-98.
[4] Calcraft, P.J. et al. (2009) Nature 459, 596-600.
[5] Ogunbayo, O.A. et al. (2011) J Biol Chem 286, 9136-40.
[6] Lee, H.C. (2012) J Biol Chem 287, 31633-40.
[7] Cantó, C. et al. (2012) Cell Metab 15, 838-47.
[8] Escande, C. et al. (2013) Diabetes 62, 1084-93.
[9] Malavasi, F. et al. (2011) Blood 118, 3470-8.
[10] Deaglio, S. et al. (2010) Semin Cancer Biol 20, 416-423.
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| | CD38 Antibody Preparation Products And Raw materials |
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