| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
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| Product Name: | BMP-22 | | Synonyms: | BMP22,BMP 22;Phosphonic acid, P-[(4-pentadecylphenyl)methyl]-;p-[(4-pentadecylphenyl)methyl]-phosphonic acid;4-Pentadecylbenzylphosphonic acid | | CAS: | 1306684-90-1 | | MF: | C22H39O3P | | MW: | 382.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1306684-90-1.mol |  |
| | BMP-22 Chemical Properties |
| Boiling point | 533.2±53.0 °C(Predicted) | | density | 1.027±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid | | pka | 2.25±0.10(Predicted) | | InChIKey | XWVBRTAQHMKHCE-UHFFFAOYSA-N | | SMILES | CCCCCCCCCCCCCCCC1=CC=C(CP(O)(O)=O)C=C1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | BMP-22 Usage And Synthesis |
| Description | BMP-22 is an inhibitor of autotaxin. It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7. BMP-22 inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC) and inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis. | | Uses | 4-Pentadecylbenzylphosphonic acid is an Autotaxin (ATX) inhibitor. 4-Pentadecylbenzylphosphonic acid has antitumor activity[1]. | | References | [1] Fells JI, et al. Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface. Mol Pharmacol. 2013 Sep;84(3):415-24. DOI:10.1124/mol.113.087080 |
| | BMP-22 Preparation Products And Raw materials |
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