Bromamphenicol manufacturers
- Bromamphenicol
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- $215.00
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2025-12-22
- CAS:17371-30-1
- Purity:
- Supply Ability: 10g
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| | Bromamphenicol Basic information |
| Product Name: | Bromamphenicol | | Synonyms: | Acetamide, 2,2-dibromo-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]- (9CI);R-(R*,R*)]-2,2-dibromo-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-acetamide | | CAS: | 17371-30-1 | | MF: | C11H12Br2N2O5 | | MW: | 412.03 | | EINECS: | | | Product Categories: | | | Mol File: | 17371-30-1.mol |  |
| | Bromamphenicol Chemical Properties |
| Boiling point | 664.4±55.0 °C(Predicted) | | density | 1.939±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | A crystalline solid | | pka | 11.14±0.46(Predicted) |
| | Bromamphenicol Usage And Synthesis |
| Description | Bromamphenicol is a dibrominated derivative of the antibiotic chloramphenicol.1 It inhibits rat liver mitochondrial and E. coli protein synthesis by 90.6 and 98.8%, respectively, when used at a concentration of 93 μM, and inhibits DNA synthesis in human lymphoblastoid cells by 83% at 1 mM. Bromamphenicol can also bind to the major adhesin subunit DraE from E. coli.2 | | Uses | Bromamphenicol (Compound Ib) is a derivative of chloramphenicol (HY-B0239), and exhibits antibacterial activity. Bromamphenicol binds to S50 ribosomal subunit, interfers with the activity of peptidyl transferase, and exhibits inhibitory activity against protein synthesis[1]. | | References | 1. Manyan, D.R., Arimura, G.K., and Yunis, A.A. Comparative metabolic effects of chloramphenicol analogues Mol. Pharmacol. 11(5),520-527(1975).
2. Pettigrew, D.M., Roversi, P., Davies, S.G., et al. A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol Acta Crystallogr. D Biol. Crystallogr. 65(Pt 6),513-522(2009). |
| | Bromamphenicol Preparation Products And Raw materials |
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