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| | RCC1 Antibody Chemical Properties |
| | RCC1 Antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | The Ras family small GTPase Ran is involved in nuclear envelope formation, assembly of the mitotic spindle, and nuclear transport. Like other small GTPases, Ran is active in its GTP-bound form and inactive in its GDP-bound form. Nuclear RanGTP concentration is maintained through nuclear localization of guanine nucleotide exchange factor activity, which catalyzes the exchange of bound GDP for GTP. Regulator of chromatin condensation 1 is the only known RanGEF. RCC1 is dynamically chromatin-bound throughout the cell cycle, and this localization is required for mitosis to proceed normally. Appropriate association of RCC1 with chromatin is regulated through amino-terminal phosphorylation and methylation. RCC1 regulation of RanGTP levels in response to histone modifications regulates nuclear import during apoptosis. In mitosis RCC1 is phosphorylated at Ser11, possibly by cyclin B/cdc2. This phosphorylation may play a role in RCC1 interaction with chromatin and RCC1 RanGEF activity. | | References | [1] Quimby, B.B. and Dasso, M. (2003) Curr Opin Cell Biol 15, 338-44.
[2] Hetzer, M. et al. (2002) Nat Cell Biol 4, E177-84.
[3] Moore, W. et al. (2002) Curr Biol 12, 1442-7.
[4] Ohtsubo, M. et al. (1989) J Cell Biol 109, 1389-97.
[5] Li, H.Y. and Zheng, Y. (2004) Genes Dev 18, 512-27.
[6] Hutchins, J.R. et al. (2004) Curr Biol 14, 1099-1104.
[7] Chen, T. et al. (2007) Nat Cell Biol 9, 596-603.
[8] Wong, C.H. et al. (2009) Nat Cell Biol 11, 36-45.
[9] Horiike, Y. et al. (2009) Mol Biol Rep 36, 717-23.
[10] Dephoure, N. et al. (2008) Proc Natl Acad Sci U S A 105, 10762-7.
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| | RCC1 Antibody Preparation Products And Raw materials |
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