| Company Name: |
Shanghai Universal Biotech Co.,Ltd
|
| Tel: |
15921930842 15921930842 |
| Email: |
yh-wang@univ-bio.com |
| Products Intro: |
Product Name:WTAP Antibody
Package:100ul Remarks: 见优宁维官网
|
| Company Name: |
Hubei Ipodix Biotechnology Co.,Ltd.
|
| Tel: |
18007124176 19384116026 |
| Email: |
2706668885@qq.com |
| Products Intro: |
Product Name:WTAP antibody
Purity:99% Package:50ul/RMB 1280;100ul/RMB 2180
|
| Company Name: |
CUSABIO TECHNOLOGY LLC
|
| Tel: |
027-87196173 |
| Email: |
cusabio@163.com |
| Products Intro: |
Product Name:WTAP Antibody
|
| Company Name: |
Hubei Serenity BioSolutions Co., Ltd.
|
| Tel: |
027-19371278702 18008634902 |
| Email: |
19384116026@163.com |
| Products Intro: |
Product Name:Mouse Monoclonal WTAP Antibody
Package:20μl;50μl;100μl
|
| Company Name: |
GeneTex, Inc.
|
| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
international@genetex.com |
| Products Intro: |
Product Name:WTAP antibody
|
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| Product Name: | WTAP antibody | | Synonyms: | WTAP antibody;Mouse Monoclonal WTAP Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![WTAP antibody Structure]() |
| | WTAP antibody Chemical Properties |
| | WTAP antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | Methyltransferase-like protein 3 and methyltransferase-like protein 14 are the two catalytic subunits of an N6-methyltransferase complex that methylates adenosine residues in RNA. Methylation of adenosine residues regulates mRNA splicing, processing, translation efficiency, editing and stability, in addition to regulating primary miRNA processing, and is critical for proper regulation of the circadian clock, embryonic stem cell self-renewal, immune tolerance, response to various stimuli, meiosis and mouse fertility. In this complex, METTL3 functions as the catalytic methyltransferase subunit and METTL14 functions as the target recognition subunit by binding to RNA. In addition, the Wilms' tumor 1-associating protein functions as a regulatory subunit and is required for accumulation of the complex to nuclear speckles, which are sites of RNA processing. Several studies suggest a role for this complex in cancer. METTL3 expression is elevated in lung adenocarcinoma where it promotes growth, survival, and invasion of human lung cancer cells. In addition, WTAP is overexpressed in a number of different cancers and positively regulates cell migration and invasion in glioblastoma and cholangiocarcinoma. | | References | [1] Liu, J. et al. (2014) Nat Chem Biol 10, 93-5.
[2] Yue, Y. et al. (2015) Genes Dev 29, 1343-55.
[3] Wu, R. et al. (2016) Mol Biotechnol 58, 450-9.
[4] Wang, X. et al. (2016) Nature 534, 575-8.
[5] Ping, X.L. et al. (2014) Cell Res 24, 177-89.
[6] Lin, S. et al. (2016) Mol Cell 62, 335-45.
[7] Jin, D.I. et al. (2012) Cancer Sci 103, 2102-9.
[8] Jo, H.J. et al. (2013) J Gastroenterol 48, 1271-82. |
| | WTAP antibody Preparation Products And Raw materials |
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