| Company Name: |
cjbscvictory |
| Tel: |
13348960310 13348960310 |
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Bax activator-1 manufacturers
- Bax activator-1
-
- $1520.00
-
2026-04-21
- CAS:1638526-94-9
- Purity:
- Supply Ability: 10g
- Bax activator-1
-
- $1520.00
-
2025-07-20
- CAS:1638526-94-9
- Purity:
- Supply Ability: 10g
|
| | Bax activator-1 Basic information |
| Product Name: | Bax activator-1 | | Synonyms: | Bax activator-1;Bax activator compound 106;Methanone, [5-[(3,4-dimethylphenyl)methyl]-4,5,6,7-tetrahydro-1-[(3-methoxyphenyl)methyl]-1H-pyrazolo[4,3-c]pyridin-3-yl][(3R)-3-hydroxy-1-piperidinyl]-;Bax activator 1,Bax activator1;Bax-activator-106 | | CAS: | 1638526-94-9 | | MF: | C29H36N4O3 | | MW: | 488.62 | | EINECS: | | | Product Categories: | | | Mol File: | 1638526-94-9.mol |  |
| | Bax activator-1 Chemical Properties |
| Boiling point | 712.8±60.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | pka | 14.35±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | Bax activator-1 Usage And Synthesis |
| Description | Bax-activator-106 is a specific Bax agonist. It acts by promoting Bax-dependent but not Bak-dependent apoptosis. | | Uses | Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis[1]. | | in vivo | Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice[1]. | Animal Model: | Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells)[1] | | Dosage: | 40 mg/kg | | Administration: | Given i.p., each day for 13 days | | Result: | Exhibited anti-tumor activity as a single-agent. |
| | IC 50 | Bax | | References | [1] Zhao G, et al. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Mol Cell Biol. 2014 Apr;34(7):1198-207. DOI:10.1128/MCB.00996-13 |
| | Bax activator-1 Preparation Products And Raw materials |
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