| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:BY27
CAS:2247236-59-3
Purity:99% Package:1mg;2mg;5mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:BY27
CAS:2247236-59-3
Purity:99.68% Package:1removed
|
BY27 manufacturers
- BY27
-
- $290.00
-
2026-07-15
- CAS:2247236-59-3
- Purity: 99.87%
- Supply Ability: 10g
- BY27
-
- $290.00
-
2026-07-15
- CAS:2247236-59-3
- Purity: 99.87%
- Supply Ability: 10g
|
| Product Name: | BY27 | | Synonyms: | BY27;4H-[1,2,4]Triazolo[4,3-a][1]benzazepin-6-amine, N-(4-chlorophenyl)-5,6-dihydro-1-methyl-8-(1-methyl-1H-pyrazol-4-yl)-, (6R)-;BY27,BY-27 | | CAS: | 2247236-59-3 | | MF: | C22H21ClN6 | | MW: | 404.9 | | EINECS: | | | Product Categories: | | | Mol File: | 2247236-59-3.mol |  |
| Description | BY27 is a novel potent and selective BET BD2 inhibitor. | | Uses | BY27 is a potent and selective BET BD2 inhibitor, shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT. Anti-cancer activity[1]. | | IC 50 | BRD2 BD2: 3.1 nM (Ki); BRD2 BD1: 95.5 nM (Ki); BRD3 BD2: 5.3 nM (Ki); BRD3 BD1: 77.9 nM (Ki); BRD4 BD2: 7.3 nM (Ki); BRD4 BD1: 80 nM (Ki); BRD2 BD2: 1.2 nM (Kd); BRD2 BD1: 45 nM (Kd); BRD3 BD2: 2.6 nM (Kd); BRD3 BD1: 12 nM (Kd); BRD4 BD2: 3.5 nM (Kd); BRD4 BD1: 26 nM (Kd); BRDT BD2: 3 nM (Kd); BRDT BD1: 64 nM (Kd) | | References | [1] Chen D, et al. Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins. Eur J Med Chem. 2019 Aug 21;182:111633. DOI:10.1016/j.ejmech.2019.111633 |
| | BY27 Preparation Products And Raw materials |
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