(4-Chlorophenyl)(3-hydroxyphenyl)methanone

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CAS:62810-39-3
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CAS:62810-39-3
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Products Intro: Product Name:(4-Chlorophenyl)(3-hydroxyphenyl)methanone
CAS:62810-39-3
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(4-Chlorophenyl)(3-hydroxyphenyl)methanone Basic information
Product Name:(4-Chlorophenyl)(3-hydroxyphenyl)methanone
Synonyms:(4-Chlorophenyl)(3-hydroxyphenyl)methanone;-Chloro-3-hydroxy-benzophenone;4’-Chloro-3-hydroxy-benzophenone;Methanone, (4-chlorophenyl)(3-hydroxyphenyl)-;Fenofibrate Impurity 33;Pyrotinib Impurity 21
CAS:62810-39-3
MF:C13H9ClO2
MW:232.66
EINECS:
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Mol File:62810-39-3.mol
(4-Chlorophenyl)(3-hydroxyphenyl)methanone Structure
(4-Chlorophenyl)(3-hydroxyphenyl)methanone Chemical Properties
Melting point 154–155°C
Boiling point 410.3±30.0 °C(Predicted)
density 1.307±0.06 g/cm3(Predicted)
pka8.97±0.10(Predicted)
Safety Information
MSDS Information
(4-Chlorophenyl)(3-hydroxyphenyl)methanone Usage And Synthesis
Uses4’-Chloro-3-hydroxy-benzophenone is an impurity of Fenofibric acid (F248650), which is an active metabolite of Fenofibrate (F248640). 4’-Chloro-3-hydroxy-benzophenone can also be used to develop treatments for tuberculosis.
PreparationPreparation by diazotization of 3-amino-4?- chlorobenzo-phenone (SM), followed by hydrolysis of the diazonium salt obtained (81%), (84%). SM was obtained by Friedel–Crafts acylation of chlorobenzene with m-nitro-benzoyl chloride, followed by reduction of the resulting 4-chloro- 3?-nitrobenzophenone.
(4-Chlorophenyl)(3-hydroxyphenyl)methanone Preparation Products And Raw materials
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