| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Tel: |
0573-85285100 18627885956 |
| Email: |
isenchem@163.com |
| Products Intro: |
Product Name:isenchem
CAS:945628-66-0
Purity:98% (HPLC或者GC) Package:25g,100g,500g;1kg
|
| Company Name: |
Hangzhou Dingyan Chem Co., LTD
|
| Tel: |
0571-87157530-8001 13616748242 |
| Email: |
sales@dingyanchem.com |
| Products Intro: |
Product Name:S-cEt-G phosphoramidite
CAS:945628-66-0
Purity:99% HPLC Package:5KG;2KG
|
|
| | (1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl) - 3- (2- Isobutyramido- Basic information |
| Product Name: | (1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl) - 3- (2- Isobutyramido- | | Synonyms: | (1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl) - 3- (2- Isobutyramido-;Propanamide, N-[9-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methyl-;N6-Bz-2'-O-4'-G-Locked-Gr-CET-Phosphoramidite;(1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl);(1s,3r,4r,6s,7s)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(2-isobutyramido-6-oxo-1h-purin-9(6h)-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-7-yl 2-cyanoethyl diisopropylphosphoramidite;CET-rG(ibu) Phosphoramidite;S-cEt-G(iBu)-CE-Phosphoramidite;S-cEt-G(ibu) phosphoramidite | | CAS: | 945628-66-0 | | MF: | C46H56N7O9P | | MW: | 881.95 | | EINECS: | | | Product Categories: | Amidite | | Mol File: | 945628-66-0.mol |  |
| | (1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl) - 3- (2- Isobutyramido- Chemical Properties |
| form | Solid | | pka | 8.68±0.20(Predicted) | | color | White to off-white |
| | (1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl) - 3- (2- Isobutyramido- Usage And Synthesis |
| Uses | 5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity[1][2]. | | References | [1] Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. DOI:10.1093/nar/gkab047
[2] Seth PP, et al. Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. J Org Chem. 2010 Mar 5;75(5):1569-81. DOI:10.1021/jo902560f
[3] Vasquez G, et al., Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. DOI:10.1093/nar/gkab047 |
| | (1S, 3R, 4R, 6S, 7S) - 1- ((Bis(4- Methoxyphenyl) (Phenyl) Methoxy) Methyl) - 3- (2- Isobutyramido- Preparation Products And Raw materials |
|