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Zhengzhou HSH Science & Technology Co., Ltd.
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0371-55932928 18937192232 |
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| Products Intro: |
Product Name:ML 604440
CAS:1140517-08-3
Purity:98% HPLC Package:100g;10g;5g;1g;500mg;250mg;100mg;10mg;5mg
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ML 604440 manufacturers
- ML604440
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- $117.00 / 1mg
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2026-04-10
- CAS:1140517-08-3
- Min. Order:
- Purity: 97.06%
- Supply Ability: 10g
- ML604440
-
- $117.00 / 1mg
-
2026-04-10
- CAS:1140517-08-3
- Min. Order:
- Purity: 97.06%
- Supply Ability: 10g
|
| | ML 604440 Basic information |
| Product Name: | ML 604440 | | Synonyms: | ML 604440;Boronic acid, B-[(1R)-3-methyl-1-[[2-methyl-1-oxo-2-[[2-(trifluoromethyl)benzoyl]amino]propyl]amino]butyl]-;(R)-(3-Methyl-1-(2-methyl-2-(2-(trifluoromethyl)benzamido)propanamido)butyl)boronic acid;ML604440, 10 mM in DMSO;CD4+T cell,human PBMCs,Inhibitor,ML 604440,Proteasome,ML604440,LMP7-deficient mice splenocytes,EAE,cell-permeable,ML-604440,inhibit,autoimmune disease,experimental colitis | | CAS: | 1140517-08-3 | | MF: | C17H24BF3N2O4 | | MW: | 388.19 | | EINECS: | | | Product Categories: | | | Mol File: | 1140517-08-3.mol |  |
| | ML 604440 Chemical Properties |
| density | 1.216±0.06 g/cm3(Predicted) | | form | Solid | | pka | 9.72±0.43(Predicted) | | color | White to yellow |
| | ML 604440 Usage And Synthesis |
| Uses | ML604440 is a specific and cell-permeable Proteasome β1i (LMP2) subunit inhibitor. ML604440 can be used in experimental colitis, EAE and autoimmune disease research. ML604440 shows synergistic effects and advantageous when combined with LMP7 inhibitor[1][2][3]. | | in vivo | ML604440 (intraperitoneal injection; 10 mg/kg; once daily; 7 d) treatment inhibits LMP2 in vivo, shows no significant changes in platelet counts[3]. | Animal Model: | Male C57BL/6J mice (6-8-wks old) injected with anti-platelet monoclonal antibody[3] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection; 10 mg/kg; once daily; 7 days | | Result: | Inhibited LMP2 in vivo.
Showed no significant improvement in platelet counts in mice immunized by monoclonal rat anti-mouse CD41 platelet antibody. |
| | References | [1] de Bruin G, et al. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014 Jul 24;57(14):6197-209 DOI:10.1021/jm500716s
[2] Basler M, et al. Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep. 2018 Dec;19(12). pii: e46512. DOI:10.15252/embr.201846512
[3] Sheng-Hong Du, et al. Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia. Front Immunol. 2021 Jan 20;11:603278. DOI:10.3389/fimmu.2020.603278 |
| | ML 604440 Preparation Products And Raw materials |
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