| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Aclimostat
CAS:2082752-83-6
Package:25mg/RMB 10600
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| Company Name: |
CLEARSYNTH LABS LTD.
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| Tel: |
+91-22-45045900 |
| Email: |
sales@clearsynth.com |
| Products Intro: |
Product Name:Aclimostat
CAS:2082752-83-6
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| | ZGN-1061 Basic information |
| Product Name: | ZGN-1061 | | Synonyms: | ZGN-1061;Aclimostat;1-Azetidinecarboxylic acid, 3-[2-(4-morpholinyl)ethyl]-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester | | CAS: | 2082752-83-6 | | MF: | C26H42N2O6 | | MW: | 478.62 | | EINECS: | | | Product Categories: | | | Mol File: | 2082752-83-6.mol |  |
| | ZGN-1061 Chemical Properties |
| Boiling point | 571.8±50.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | form | Solid | | pka | 7.42±0.10(Predicted) | | color | White to off-white |
| | ZGN-1061 Usage And Synthesis |
| Uses | Aclimostat (ZGN-1061) is a potent inhibitor of the MetAP2 enzyme and displays favorable efficacy and safety in preclinical studies. ZGN-1061 produced similar efficacy as beloranib for weight loss, improvements in metabolic parameters in a mouse model of obesity and insulin resistance, and concordant changes in gene transcription in HepG2 cells[1]. | | References | [1] Burkey BF, Hoglen NC, Inskeep P, Wyman M, Hughes TE, Vath JE. Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061. J Pharmacol Exp Ther. 2018 May;365(2):301-313. DOI:10.1124/jpet.117.246272 |
| | ZGN-1061 Preparation Products And Raw materials |
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