5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester

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5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Basic information
Product Name:5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester
Synonyms:5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester;Benzeneacetic acid, 5-(1,1-dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-, methyl ester;5-?(1,?1-?Dimethylethyl)?-?2-?hydroxy-?α,?α-?dimethyl-?4-?nitro-benzeneacetic Acid Methyl Ester
CAS:1246213-34-2
MF:C15H21NO5
MW:295.34
EINECS:
Product Categories:
Mol File:1246213-34-2.mol
5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Structure
5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Chemical Properties
Boiling point 386.8±42.0 °C(Predicted)
density 1.166±0.06 g/cm3(Predicted)
solubility Chloroform; Dichloromethane; Methanol
pka8.01±0.10(Predicted)
form Solid
color Pale Yellow
Safety Information
MSDS Information
5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Usage And Synthesis
Uses5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester is an intermediate in synthesizing Ivacaftor Carboxylic Acid (I940605). It is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.
5-(1,1-Dimethylethyl)-2-hydroxy-α,α-dimethyl-4-nitro-benzeneacetic Acid Methyl Ester Preparation Products And Raw materials
Raw materials2-BroMo-4-tert-butyl-5-nitro-phenol-->Dimethylketene methyl trimethylsilyl acetal
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