| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:HFI-419
CAS:1110650-72-0
Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Products Intro: |
Product Name:IRAP Inhibitor, HFI-419
CAS:1110650-72-0
|
| Company Name: |
Enamine Ltd
|
| Tel: |
+1 732 274 9150 |
| Email: |
sales_usa@enamine.net |
| Products Intro: |
Product Name:HFI-419
CAS:1110650-72-0
|
HFI-419 manufacturers
- HFI-419
-
- $1980.00 / 50mg
-
2026-04-20
- CAS:1110650-72-0
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | HFI-419 Basic information |
| Product Name: | HFI-419 | | Synonyms: | HFI-419;4H-1-Benzopyran-3-carboxylic acid, 2-(acetylamino)-7-hydroxy-4-(3-pyridinyl)-, ethyl ester | | CAS: | 1110650-72-0 | | MF: | C19H18N2O5 | | MW: | 354.36 | | EINECS: | | | Product Categories: | | | Mol File: | 1110650-72-0.mol |  |
| | HFI-419 Chemical Properties |
| Boiling point | 584.9±50.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 100mg/mL | | form | powder | | pka | 9.13±0.70(Predicted) | | color | off-white | | InChI | 1S/C19H18N2O5/c1-3-25-19(24)17-16(12-5-4-8-20-10-12)14-7-6-13(23)9-15(14)26-18(17)21-11(2)22/h4-10,16,23H,3H2,1-2H3,(H,21,22) | | InChIKey | GGBHINRNYAAYMX-UHFFFAOYSA-N | | SMILES | CCOC(=O)C1=C(OC2=C(C1C3=CN=CC=C3)C=CC(=C2)O)NC(=O)C |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | HFI-419 Usage And Synthesis |
| Uses | The racemic mixture of an aqueous soluble (at least 50 µg/mL or 140 µM at pH 6.5) pyridinyl-4H-benzopyran compound that inhibits insulin-regulated (IRAP) aminopeptidase activity by competing against substrate for IRAP extracellular catalytic site binding (Ki = 0.48 µM; using 25 µM Leu-AMC as substrate) with concomitant interaction with active site zinc via its acetamide, while displaying little potency against glucose-6-phosphatase, aminopeptidase N, ACE1, leukotriene A4 hydrolase, or ER-associated aminopeptidases 1 & 2 (≤13% inhibition at 100 µM). Reported to boost 1 mM dibutyryl cAMP-evoked glucose uptake in cultured rat hippocampal slices (68% higher uptake in 5 min than dbcAMP alone without 100 nM HFI-419) in vitro and exhibit in vivo memory-enhancing efficacay in an object recognition test when administered directly into the cerebral lateral ventricle of rats via a cannula implant (0.1 or 1.0 nmol/2 µL/rat). HFI-419 is reported to hydrolyze into slightly less potent HFI-142 (Ki = 2.0 µM) after i.v. (plasma t1/2 = 11 min; 2 mg/kg) or i.p (plasma t1/2 = 4.6 h; 10 mg/kg) injection in rats, although HFI-142 is more stable and likely exhibits better blood-brain permeability (Blood:Brain HFI-142 ratio = 3.36 and 0.38, respectively, 0.5 and 4 h post single 3 mg HFI-419/kg i.v. injection). | | Biological Activity | Cell permeable: yes', 'Primary Target
IRAP', 'Reversible: yes |
| | HFI-419 Preparation Products And Raw materials |
|