BC-DXI-843 manufacturers
- BC-DXI-843
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- $34.00
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2026-07-15
- CAS:2421117-98-6
- Purity: 98.85%
- Supply Ability: 10g
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| | BC-DXI-843 Basic information |
| Product Name: | BC-DXI-843 | | Synonyms: | BC-DXI-843;1H-Indole-3-propanamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-α-[[(4-methylphenyl)sulfonyl]amino]-, (αS)-;BC-Dxl-843;Inhibitor,lung,A549,BCDXI843,AIMP2-DX2,cancer,inhibit,BC DXI 843;(S)-3-(1H-Indol-3-yl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-2-(4-methylphenylsulfonamido)propanamide;(S)-3-(1H-Indol-3-yl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-2-(4-methylphenylsulfonamido)propanamide , BC-DXI-843;BC-DXI-843, 10 mM in DMSO | | CAS: | 2421117-98-6 | | MF: | C28H26N4O4S2 | | MW: | 546.66 | | EINECS: | | | Product Categories: | | | Mol File: | 2421117-98-6.mol |  |
| | BC-DXI-843 Chemical Properties |
| density | 1.381±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 7.76±0.50(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | BC-DXI-843 Usage And Synthesis |
| Uses | BC-DXI-843 is a potent and specific AIMP2-DX2 inhibitor with an IC50 of 0.92 μM, more than 100-fold selectivity over AIMP2 (IC50 >100 μM) in a luciferase assay. BC-DXI-843 acts as a promising lead targeting AIMP2-DX2 in lung cancer[1]. | | in vivo | BC-DXI-843 (50 mg/kg; intraperitoneally administered; every other day for 15 days) demonstrates in vivo efficacy in a tumor xenograft mouse model (H460 cells)[1]. | Animal Model: | 7-week-old female BALB/cSLC-nu/nu mice bearing H460 cells xenograft[1] | | Dosage: | 50 mg/kg | | Administration: | Intraperitoneally administered; every other day for 15 days | | Result: | The embedded tumor volume gradually declined after BC-DXI-843administration, but no changes in body weight were observed. The weight of the excised tumors after sacrifice had decreased in mice. |
| | References | [1] Aneesh Sivaraman, et al. Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy. J Med Chem. 2020 May 28;63(10):5139-5158. DOI:10.1021/acs.jmedchem.9b01961 |
| | BC-DXI-843 Preparation Products And Raw materials |
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