4-Chloro-1H-pyrazolo[3,4-d]pyrimidine

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Suppliers list

Company Name:	BeiJing Hwrk Chemicals Limted
Tel:	0757-86329057 18934348241
Email:	sales4.gd@hwrkchemical.com

Company Name:	Wuhan Chemwish Technology Co., Ltd
Tel:	86-027-67849912
Email:	sales@chemwish.com

Company Name:	JinYan Chemicals(ShangHai) Co.,Ltd.
Tel:	13817811078
Email:	sales@jingyan-chemical.com

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine manufacturers

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Basic information

Product Name:	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine
Synonyms:	IFLAB-BB F0909-0060;4-CHLORO-1H-PYRAZOLO3,4-DPYRIMIDINE;AKOS BBS-00002106;1H-Pyrazolo[3,4-d]pyrimidine, 4-chloro-;4-Chloropyrazolo[3,4-d]pyrimidine;NSC 4937;4-chloro-1H-pyrazolo[3;4-Chlor-1(2)Hpyrazolo[3,4-d]pyriMidine
CAS:	5399-92-8
MF:	C5H3ClN4
MW:	154.56
EINECS:	640-617-8
Product Categories:	Heterocycle-Pyrimidine series;Halides;Bases & Related Reagents;Heterocycles;Inhibitors;Nucleotides;Fused Ring Systems
Mol File:	5399-92-8.mol

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties

Melting point	>350C
Boiling point	224.6±50.0 °C(Predicted)
density	1.84±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	10.16±0.20(Predicted)
color	Yellow to Orange
CAS DataBase Reference	5399-92-8(CAS DataBase Reference)

Safety Information

MSDS Information

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Usage And Synthesis

Chemical Properties	Pale Yellow Solid
Uses	Has a SK channel blocker effect.
Synthesis	5305-40-8 5399-92-8 Synthesis of compound 4.1. Hydrazine hydrate (11.5 mL, 23.7 mmol) was slowly added dropwise to a 1,4-dioxane solution (600 mL) containing 4,6-dichloro-5-pyrimidinecarboxaldehyde (40.0 g, 22.6 mmol) and triethylamine (30 mL, 22 mmol) under the cooling of an ice bath, and the temperature of the reaction was controlled to be no more than 20°C. The reaction temperature was controlled to be no higher than 20°C. After dropwise addition, the reaction mixture was gradually warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the precipitate was collected by filtration. The filtrate was concentrated under reduced pressure to give compound 4.1 (29 g, 83% yield) in the form of a light yellow solid. The product was characterized by 1H NMR (400.13 MHz, DMSO-d6) and mass spectrometry: 1H NMR δ 14.52 (br.s, 1H), 8.83 (s, 1H), 8.45 (s, 1H); MS m/z 155 [M + 1]+.
References	[1] Patent: US2009/5359, 2009, A1. Location in patent: Page/Page column 18 [2] Patent: WO2008/153947, 2008, A2. Location in patent: Page/Page column 42; 63-64 [3] Molecules, 2017, vol. 22, # 4, [4] Patent: CN106496232, 2017, A. Location in patent: Paragraph 0049; 0050; 0051; 0052 [5] Patent: CN107383014, 2017, A. Location in patent: Paragraph 0075; 0076; 0077; 0078

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials	4H-Pyrazolo[3,4-d]pyrimidin-4-one, 2,5-dihydro- (9CI)-->Allopurinol-->Hydrazine hydrate-->4,6-Dichloropyrimidine-5-carbaldehyde-->Triethylamine-->1,4-Dioxane-->HYDRAZINE
Preparation Products	3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine-->(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine-->4-(1H-Pyrazolo[3,4-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester-->1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-methyl- (9CI)-->tert-butyl 4-chloro-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate

Tag:4-Chloro-1H-pyrazolo[3,4-d]pyrimidine(5399-92-8) Related Product Information

Trazodone Zolpidem tartrate Sodium cloxacillin monohydrate Cloxacillin Chlorzoxazone Pyrimidine 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE ethyl 5,7-dichloro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylate Zolpidem Difluorochloromethane 4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine 7-Chloro-5-methylpyrazolo[1,5-a]pyrimidine 4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-Chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine 4-Chloro-1-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine 4-Chloro-1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine 4-Chloro-1-(2,4-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidine 4-Chloro-1-(3,5-di-o-toluoyl-beta-D-2-deoxyribofuranosyl)pyrazolo[3,4-d]pyrimidine