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2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID

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2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Suppliers list
Company Name: Standardpharm Co. Ltd.
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Products Intro: Product Name:Diclofenac Impurity 15
CAS:64118-84-9
Purity:0.99 Package:10mg;25mg;50mg;100mg
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:4'-hydroxydiclofenac
CAS:64118-84-9
Purity:99% Package:1kg,25kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:4'-Hydroxy diclofenac
CAS:64118-84-9
Package:1mg;466USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: sgtlifesciences pvt ltd
Tel: +8617013299288
Email: dj@sgtlifesciences.com
Products Intro: Product Name:4-Hydroxy Diclofenac
CAS:64118-84-9
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:2-(2-((2,6-Dichloro-4-hydroxyphenyl)amino)phenyl)aceticacid
CAS:64118-84-9
Purity:98% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing

2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID manufacturers
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Basic information
Product Name:2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID
Synonyms:(o-(2,6-dichloro-4-hydroxyanilino)phenyl)-aceticaci;(o-(2,6-dichloro-4-hydroxyanilino)phenyl)aceticacid;DICLOFENAC, 4'-HYDROXY-;4'-OHD;4-OHD;4-HYDROXY DICLOFENAC;2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID;4'-HYDROXYDICLOFENAC STANDARD
CAS:64118-84-9
MF:C14H11Cl2NO3
MW:312.15
EINECS:626-698-2
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:64118-84-9.mol
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Structure
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Chemical Properties
Melting point 178-185°C dec.
Boiling point 432.7±45.0 °C(Predicted)
density 1.520±0.06 g/cm3(Predicted)
Fp 2℃
storage temp. -20°C
solubility Soluble in DMSO, ethanol or methanol
pka4.17±0.10(Predicted)
form Solid
color White to off-white
BRN 4198042
Stability:Light Sensitive
Major Applicationclinical testing
InChI1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20)
InChIKeyKGVXVPRLBMWZLG-UHFFFAOYSA-N
SMILESOC(=O)Cc1ccccc1Nc2c(Cl)cc(O)cc2Cl
Safety Information
Hazard Codes T,N,Xn,F
Risk Statements 25-37/38-41-50/53-36-20/21/22-11
Safety Statements 26-39-45-60-61-36/37-16
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS AG6542800
HazardClass 6.1
Storage Class3 - Flammable liquids
Hazard ClassificationsAcute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2
MSDS Information
ProviderLanguage
SigmaAldrich English
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Usage And Synthesis
Description4-hydroxy Diclofenac is a CYP2C9 metabolite of the NSAID diclofenac . By inhibiting COX and subsequently suppressing PGE2 synthesis, it demonstrates anti-inflammatory and analgesic properties.
Chemical PropertiesLight Violet Solid
UsesA metabolite of Diclofenac, a nonsteroidal inflammatory compound and cyclooxygenase (COX) inhibitor.
UsesA metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor
UsesA Cytochrome P450 2C9 (CYP2C9) metabolite of diclofenac
DefinitionChEBI: An monocarboxylic acid that is the 4'-hydroxylated metabolite of diclofenac.
General Description4′-Hydroxydiclofenac is one of the metabolites of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used in human and veterinary medicine.
References[1] R J SAWCHUK. Analysis of diclofenac and four of its metabolites in human urine by HPLC.[J]. Pharmaceutical Research, 1995, 12 5: 756-762. DOI: 10.1023/a:1016276012891
[2] ü. YAAR. The role of CYP2C9 genotype in the metabolism of diclofenac in vivo and in vitro[J]. European Journal of Clinical Pharmacology, 2001, 57 1: 729-735. DOI: 10.1007/s00228-001-0376-7
[3] R YAMAZAKI. Hydrolytic activity is essential for aceclofenac to inhibit cyclooxygenase in rheumatoid synovial cells.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 289 2: 676-681.
[4] FENG ZHANG. Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb–drug interactions in antiviral therapy[J]. Acta Pharmacologica Sinica, 2021, 43 4: 1072-1081. DOI: 10.1038/s41401-021-00697-2
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Preparation Products And Raw materials
Tag:2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID(64118-84-9) Related Product Information
1-(2,6-Dichlorophenyl)-2-hydroindole 2,6-DICHLORODIPHENYLAMINE 2-(2,6-Dichloroanilino) benzaldehyde 2-[(2,6-dichlorophenyl)amino]benzoicacid Oxindole Diclofenac sodium (2-(2,6-DICHLOROANILINO)PHENYL) METHANOL 2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95% Diclofenac Impurity 7 Diclofenac Impurity 16 Phenylacetic acid 1-(2,6-Dichlorophenyl)-2-indolinone 2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID 4-Amino-3-chlorophenol hydrochloride 2-ANILINOPHENYLACETIC ACID 4-HYDROXY-2'-METHYLDIPHENYLAMINE 4'-Hydroxy diclofenac-d4 (2-(2,6-Dichloro-4-hydroxyanilino)-5-hydroxyphenyl)acetic acid