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| | 2,6-DICHLORODIPHENYLAMINE Basic information |
| Product Name: | 2,6-DICHLORODIPHENYLAMINE | | Synonyms: | 2,6-DICHLORODIPHENYLAMINE;2,6-dichloro-N-phenylaniline;N-PHENYL-2,6-DICHLOROANILINE;TIMTEC-BB SBB003229;2,6-dichlorobisaniline;2,6 Dichloro di phenol amine;,6-DICHLORODIPHENYLAMINE;Benzenamine, 2,6-dichloro-N-phenyl- | | CAS: | 15307-93-4 | | MF: | C12H9Cl2N | | MW: | 238.11 | | EINECS: | 239-349-0 | | Product Categories: | Amines;Building Blocks;C12;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Anilines, Aromatic Amines and Nitro Compounds;15307-93-4 | | Mol File: | 15307-93-4.mol |  |
| | 2,6-DICHLORODIPHENYLAMINE Chemical Properties |
| Melting point | 50-53 °C(lit.) | | Boiling point | 115 °C(Press: 0.01 Torr) | | density | 1.327±0.06 g/cm3(Predicted) | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | pka | -2.57±0.40(Predicted) | | form | Solid | | color | Pale brown | | BRN | 2725987 | | InChI | InChI=1S/C12H9Cl2N/c13-10-7-4-8-11(14)12(10)15-9-5-2-1-3-6-9/h1-8,15H | | InChIKey | HDUUZPLYVVQTKN-UHFFFAOYSA-N | | SMILES | C1(NC2=CC=CC=C2)=C(Cl)C=CC=C1Cl | | CAS DataBase Reference | 15307-93-4(CAS DataBase Reference) |
| | 2,6-DICHLORODIPHENYLAMINE Usage And Synthesis |
| Chemical Properties | Light brown powder | | Uses | N-(2,6-Dichlorophenyl)aniline is an analog of Diclofenac (D436450), a nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor. | | Synthesis | The general procedure for the synthesis of 2,6-dichloro-N-phenylaniline from the compound (CAS:146607-19-4) was as follows: compound II (272 g, 0.92 mol) was added to a dry four-necked flask with toluene (800 g, 8.7 mol) and heated to 90 °C. Sodium hydroxide (total 14.8 g, 0.37 mol) was added in three portions under stirring, followed by refluxing the reaction mixture for 3 hours. After completion of the reaction, the mixture was cooled to below 80°C. 184 mL of distilled water was added to the reaction flask and the temperature was raised to 90 °C with continuous stirring for 1 hour. The reaction solution was transferred to a dispensing funnel and washed sequentially by adding 46 mL of water and 28 mL of hydrochloric acid. The washed organic phase was transferred to a distillation flask and toluene was removed by distillation under reduced pressure. Finally 203.4 g of light yellow solid product was obtained as N-(2,6-dichlorophenyl)aniline (Compound III) in 93% yield. | | References | [1] Patent: CN106905178, 2017, A. Location in patent: Paragraph 0021; 0040; 0041 |
| | 2,6-DICHLORODIPHENYLAMINE Preparation Products And Raw materials |
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