- Ro 25-6981
-
- $35.00 / 1mg
-
2026-03-13
- CAS:169274-78-6
- Min. Order:
- Purity: 99.88%
- Supply Ability: 10g
- Ro 25-6981
-
- $35.00 / 1mg
-
2026-03-13
- CAS:169274-78-6
- Min. Order:
- Purity: 99.88%
- Supply Ability: 10g
|
| | (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE Basic information |
| Product Name: | (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE | | Synonyms: | RO 25-6981 MALEATE;(alpha-R,beta-S)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanolmaleate;Ro 25-6981 maleate salt;(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE;(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanolmaleate;(aR,bS)-a-(4-Hydroxyphenyl)-b-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate;(alphaR,betaS)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol;CS-2705 | | CAS: | 169274-78-6 | | MF: | C22H29NO2 | | MW: | 339.47 | | EINECS: | | | Product Categories: | Glutamate;API | | Mol File: | 169274-78-6.mol |  |
| | (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE Chemical Properties |
| Boiling point | 512.4±45.0 °C(Predicted) | | density | 1.116±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at RT | | solubility | DMSO : 100 mg/mL (294.58 mM; Need ultrasonic) | | pka | 10.01±0.26(Predicted) | | form | Powder | | color | White to off-white | | Water Solubility | H2O: 25mM | | InChI | 1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1 | | InChIKey | WVZSEUPGUDIELE-HTAPYJJXSA-N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE Usage And Synthesis |
| Uses | Ro 25-6981 maleate is a potent NMDA receptor antagonist. | | Definition | ChEBI: Ro 25-6981 is a member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor. It has a role as a NMDA receptor antagonist, an anticonvulsant, an antidepressant and a neuroprotective agent. It is a member of piperidines, a member of phenols, a secondary alcohol, a tertiary amino compound and a member of benzenes. It is a conjugate base of a Ro 25-6981(1+). | | Biological Activity | Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC 50 values are 0.009 and 52 μ M for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro . | | in vivo | Ro 25-6981 (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1].
Ro 25-6981 (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2].
Ro 25-6981 (800 μg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia[3]. | Animal Model: | 6-OHDA-lesioned rats[1] | | Dosage: | 0.39-12.5 mg/kg | | Administration: | I.p. | | Result: | Dose-dependently induced contraversive tight nose-to-tail rotations, and induced a weak ipsiversive circling response indicating a mild unspecific stimulatory action of the compound. |
| Animal Model: | Male albino rats of Wistar strain[2] | | Dosage: | 1, 3 mg/kg | | Administration: | I.p. | | Result: | Caused a significant decrease of N1–P2 amplitude at higher stimulation intensities AT 3 mg/kg, and exhibited age- and activation-dependent anticonvulsant action at early postnatal development. |
| | IC 50 | NMDA Receptor |
| | (AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE Preparation Products And Raw materials |
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