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| | ANTI-FEN-1 Basic information |
| Product Name: | ANTI-FEN-1 | | Synonyms: | Monoclonal Anti-C4B antibody produced in mouse;Anti-FEN1 antibody produced in rabbit;Monoclonal Anti-FEN1 antibody produced in mouse;ANTI-FEN-1;ANTI-FLAP STRUCTURE-SPECIFIC ENDONUCLEASE I;Anti-Flap endonuclease 1;Anti-hFEN-1;Anti-Maturation factor 1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-FEN-1 Structure]() |
| | ANTI-FEN-1 Chemical Properties |
| storage temp. | -20°C | | form | liquid | | biological source | rabbit |
| WGK Germany | WGK 1 | | Storage Class | 10 - Combustible liquids |
| | ANTI-FEN-1 Usage And Synthesis |
| Uses | This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. (provided by RefSeq) | | Biological Activity | Flap endonuclease 1 (FEN1) is involved in the maturation of Okazaki fragments during the synthesis of DNA lagging strands and long-patch DNA-base excision repair due to its flap-specific endonuclease (FEN) activity. It possesses 5μ exonuclease activity for processing DNA ends during DNA recombination. FEN1 plays a role in maintaining genomic stability by preserving telomere stability. Overexpression of the FEN1 gene is observed in testis, brain, and lung tumors. Mutations in the FEN1 gene are associated with several human cancers. |
| | ANTI-FEN-1 Preparation Products And Raw materials |
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