|
|
| | THIOPHENE-2-THIOCARBOXAMIDE Basic information |
| Product Name: | THIOPHENE-2-THIOCARBOXAMIDE | | Synonyms: | OTAVA-BB BB7020331311;THIOPHENE-2-THIOAMIDE;THIOPHENE-2-THIOCARBOXAMIDE;THIOPHENE-2-CARBOTHIOAMIDE;THIOPHENE-2-CARBOTHIOIC ACID AMIDE;Thiophene-2-carbothioamide, 95+%;Thiophene-2-carbothioic acid amide, 2-Carbamothioylthiophene;2-(Aminothiocarbonyl)thiophene | | CAS: | 20300-02-1 | | MF: | C5H5NS2 | | MW: | 143.23 | | EINECS: | | | Product Categories: | | | Mol File: | 20300-02-1.mol |  |
| | THIOPHENE-2-THIOCARBOXAMIDE Chemical Properties |
| Melting point | 106 °C | | Boiling point | 260℃ | | density | 1.357 | | Fp | 111℃ | | storage temp. | 2-8°C(protect from light) | | pka | 12.56±0.29(Predicted) | | form | powder to crystal | | color | White to Yellow to Green | | Water Solubility | Insoluble in water. | | BRN | 110159 | | CAS DataBase Reference | 20300-02-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 25-43 | | Safety Statements | 22-36/37/39-45-36/37 | | RIDADR | 2811 | | Hazard Note | Irritant | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 2934999090 |
| Provider | Language |
|
ALFA
| English |
| | THIOPHENE-2-THIOCARBOXAMIDE Usage And Synthesis |
| Uses | Thiophene-2-thiocarboxamide is used as a pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of thiophene-2-thioformamide from 2-thiophenecarboxamide: 2-thiophenecarboxamide (1 g, 7.86 mmol) was dissolved in dry 1,2-dimethoxyethane (30 mL). Lawesson's reagent (1.6 g, 3.9 mmol) was added and the reaction was protected under nitrogen. The reaction mixture was stirred at room temperature for 12 hours and then filtered. Subsequently, the solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10:1 to 2:1) to afford thiophene-2-thiocarboxamide (1.0 g, 88.8% yield, white solid). Thiophene-2-carbothioamide can be used directly in the subsequent reaction without further purification. | | References | [1] Patent: EP2708534, 2014, A1. Location in patent: Paragraph 0055
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 904 - 908
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 17, p. 7512 - 7523
[4] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9655 - 9662
[5] Journal of Chemical Research, 2010, # 3, p. 151 - 153 |
| | THIOPHENE-2-THIOCARBOXAMIDE Preparation Products And Raw materials |
|