化合物 Rp-cAMPS
| 中文名称 | 化合物 Rp-cAMPS |
|---|---|
| 中文同义词 | 化合物 Rp-cAMPS |
| 英文名称 | SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE |
| 英文同义词 | ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, SP-ISOMER TRIETHYLAMMONIUM SALT;ADENOSINE 3',5'-CYCLIC PHOSPHOROTHIOATE-SP, TRIETHYLAMMONIUM SALT;(R)-Adenosine;Cyclic3',5'-(hydrogenphosphorothioate)triethylammonium;(R)-Adenosine,cyclic3',5'-(hydrogenphosphorothioate)triethylammonium;Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt;adenosine-3’,5’-cyclicmonophosphorothioate,rp-isomer(rp-camps),sodiumsalt;SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE |
| CAS号 | 73208-40-9 |
| 分子式 | C16H27N6O5PS |
| 分子量 | 446.46 |
| EINECS号 | |
| 相关类别 | Cyclic Nucleotide related |
| Mol文件 | 73208-40-9.mol |
| 结构式 |  |
化合物 Rp-cAMPS 性质
| 储存条件 | −20°C |
|---|---|
| 溶解度 | 可溶于水中 |
| 形态 | 固体 |
| 颜色 | 白色 |
Rp-cAMPS，一种 cAMP 的类似物，是一种 cAMP 诱导的 PKA I 和 PKA II 活化 (Ki 分别为 12.5 µM 和 4.5 µM) 的有效的，竞争性拮抗剂。Rp-cAMPS 耐磷酸二酯酶水解。
Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)
A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.
Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 提供商 | 语言 |
|---|---|
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英文
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