2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), RP-isomer sodium salt

Request For Quotation
2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), RP-isomer sodium salt Suppliers list
Company Name: Jiangsu Synthgene Biotechnology Co.,Ltd.  
Tel: 15852554546
Email: starre@syngenebio.com
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: Shanghai meikai technology co., ltd  
Tel: 021-68689288 15300790979
Email: info@mkbio.com.cn
2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), RP-isomer sodium salt Basic information
Product Name:2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), RP-isomer sodium salt
Synonyms:2’-deoxyguanosine-5’-o-(1-thiotriphosphate),rpisomer(rp-dgtp-alpha-s),sodiumsalt;RP-DGTP-ALPHA-S SODIUM SALT;SP-DGTP-ALPHA-S SODIUM SALT;2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT;Guanosine, 2'-deoxy-, 5'→P''-ester with [P''(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)) (9CI);dGTPαS (Rp isomer) 100mM Sodium Solution;Guanosine, 2′-deoxy-, 5′→P′′-ester with [P′′(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH));Rp-dGTPαS
CAS:80902-29-0
MF:C10H12N5Na4O12P3S
MW:611.17
EINECS:
Product Categories:
Mol File:80902-29-0.mol
2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), RP-isomer sodium salt Structure
2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), RP-isomer sodium salt Chemical Properties
density 2.56±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
solubility Water: Soluble
pka1.07±0.10(predicted)
Safety Information
MSDS Information
2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), RP-isomer sodium salt Usage And Synthesis
UsesRp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates[1].
References[1] Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60(21):1682-1698. DOI:10.1021/acs.biochem.0c00944
2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), RP-isomer sodium salt Preparation Products And Raw materials
Tag:2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), RP-isomer sodium salt(80902-29-0) Related Product Information
2'-Deoxyguanosine monohydrate α-2'-Deoxyguanosine Rp-2'-Deoxy-2'-fluoroadenosine-5'-O-(1-thiotriphosphate) (sodium salt) Rp-Thymidine-5'-O-(1-thiotriphosphate) (sodium salt) Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) (sodium salt) Rp-Guanosine-5'-O-(1-thiotriphosphate) (sodium salt)