圣草酚
| 中文名称 | 圣草酚 |
|---|---|
| 中文同义词 | (S)-2-(3,4-二羟基苯基)-2,3-二氢-5,7-二羟基-4-香豆素;毛纲草酚;3',4',5,7-四羥二氫黃酮;圣草酚;圣草酚(标准品);(S)-圣草酚;毛纲草酚对照品,;圣草酚, 来源于柠檬 |
| 英文名称 | ERIODICTYOL |
| 英文同义词 | (S)-3',4',5,7-TETRAHYDROXYFLAVANONE;ERIODICTYOL;5,7,3',4'-TETRAHYDROXYFLAVANONE;2-[3,4-DIHYDROXYPHENYL]2,3-DIHYDRO-5,7-DIHYDROXY-4H-1BENZOPYRAN-4-ONE;3',4',5,7-TETRAHYDROXYFLAVANONE;(S)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4-benzopyrone;(2S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-4-one;ERIODICTYOL(SH) |
| CAS号 | 552-58-9 |
| 分子式 | C15H12O6 |
| 分子量 | 288.25 |
| EINECS号 | 209-016-4 |
| 相关类别 | 植物提取物;中药对照品;标准品;分析试剂标准品;Flavanones;chemical reagent;对照品;植提标准品;标准品-中药标准品;标准品，对照品;黄酮;标准品 -中药标准品;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol文件 | 552-58-9.mol |
| 结构式 |  |
圣草酚 性质
| 熔点 | 270°C |
|---|---|
| 沸点 | 625.2±55.0 °C(Predicted) |
| 密度 | 1.586±0.06 g/cm3(Predicted) |
| FEMA | 4715 | 2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4-CHROMANON |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于DMSO（轻微）、甲醇（非常轻微） |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.49±0.40(Predicted) |
| 颜色 | 白色至浅棕色 |
| 水溶解性 | 70mg/L(20 ºC) |
| JECFA Number | 2172 |
| BRN | 5104930 |
| 稳定性 | 吸湿性 |
| InChI | 1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2/t13-/m0/s1 |
| InChIKey | SBHXYTNGIZCORC-ZDUSSCGKSA-N |
| SMILES | Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c3ccc(O)c(O)c3 |
| CAS 数据库 | 552-58-9(CAS DataBase Reference) |
圣草酚能抗菌、抗炎，在糖尿病的发病机制中起着至关重要的作用，可以抑制 immunoglobulin E(Ig E)/antigen (Ag)诱导I型过敏反应，同时具有止痛及温热功效。Eriodictyol 是从中草药中得到的黄酮类，具有抗氧化、抗炎的功效。Eriodictyol 能够诱导 Nrf2 信号通路。Eriodictyol 还是一种流感依赖 RNA 的 RNA 聚合酶抑制剂，IC50 为 18 nM。
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Human Endogenous Metabolite
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Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ 25-35 -induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons.
Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues.
药理药效:抗氧化、抗辐射、降血脂、降血糖。
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英文
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