- 4-BROMO-3-NITRO-BENZALDEHYDE
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- $100.00 / 1KG
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2025-09-25
- CAS:163596-75-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 4-BROMO-3-NITRO-BENZALDEHYDE Basic information |
| | 4-BROMO-3-NITRO-BENZALDEHYDE Chemical Properties |
| Melting point | 104-108 °C (lit.) | | Boiling point | 289.3±30.0 °C(Predicted) | | density | 1.781±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to crystal | | color | White to Light red to Green | | λmax | 295nm(CH3CN)(lit.) | | InChI | InChI=1S/C7H4BrNO3/c8-6-2-1-5(4-10)3-7(6)9(11)12/h1-4H | | InChIKey | SAFSVELFSYQXOV-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(Br)C([N+]([O-])=O)=C1 | | CAS DataBase Reference | 163596-75-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-50-43-38-22 | | Safety Statements | 26-36-61-45-36/37 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | HS Code | 2913000090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Acute 1
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| | 4-BROMO-3-NITRO-BENZALDEHYDE Usage And Synthesis |
| Uses | 4-Bromo-3-nitrobenzaldehyde is a benzaldehyde derivative, mainly used as an intermediate component in organic synthesis. It can be used to prepare 4-Bromo-3-chlorobenzoic acid and other benzoic acid compounds. | | Synthesis | Step 1. Synthesis of 4-bromo-3-nitrobenzaldehyde: NaNO3 (5.48 g, 64.47 mmol, 1.19 eq.) was added to a 100 mL three-necked round-bottomed flask, followed by slow addition of 98% H2SO4 (60 mL). The reaction mixture was stirred continuously for 1.5 h at 10 °C. After that, 4-bromobenzaldehyde (10 g, 54.05 mmol, 1.00 eq.) was added to the reaction system and stirring was continued for 2 h at the same temperature. The reaction process was monitored by thin layer chromatography (TLC, unfolding agent ratio EtOAc:PE = 1:5). Upon completion of the reaction, 200 g of ice was added to the reaction mixture to quench the reaction. The resulting white solid product was collected by filtration and washed thoroughly with distilled water (3 x 200 mL) to yield 4-bromo-3-nitrobenzaldehyde (11.72 g, 94% yield). | | References | [1] Patent: US8080566, 2011, B1. Location in patent: Page/Page column 65
[2] Medicinal Chemistry Research, 2018, vol. 27, # 7, p. 1782 - 1791
[3] Recueil des Travaux Chimiques des Pays-Bas, 1926, vol. 45, p. 694
[4] Recueil des Travaux Chimiques des Pays-Bas, 1929, vol. 48, p. 1137
[5] Journal of the Chemical Society, 1927, p. 25 |
| | 4-BROMO-3-NITRO-BENZALDEHYDE Preparation Products And Raw materials |
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