7-Deaza-7-carbamoyladenosine hydrate

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Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Company Name: SIGMA-RBI  
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7-Deaza-7-carbamoyladenosine hydrate Basic information
Product Name:7-Deaza-7-carbamoyladenosine hydrate
Synonyms:SANGIVAMYCIN HYDRATE;7-Deaza-7-carbamoyladenosine hydrate
CAS:
MF:C12H17N5O6
MW:327.29
EINECS:
Product Categories:
Mol File:Mol File
7-Deaza-7-carbamoyladenosine hydrate Structure
7-Deaza-7-carbamoyladenosine hydrate Chemical Properties
storage temp. 2-8°C
solubility Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Slightly Soluble: 0.1-1 mg/mlH2O: Slightly Soluble: 0.1-1 mg/ml
Safety Information
Hazard Codes T+
Risk Statements 26/27/28
Safety Statements 36/37/39-45
WGK Germany 3
RTECS UY9355000
MSDS Information
ProviderLanguage
SigmaAldrich English
7-Deaza-7-carbamoyladenosine hydrate Usage And Synthesis
DescriptionSangivamycin is a nucleoside analog.1 It incorporates into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA and reduces the number of plaque-forming units (PFUs) in SARS-CoV-2-infected Vero E6 cells when used at a concentration of 72 nM. Sangivamycin (0.3 µM) induces cell cycle arrest at the G2/M phase and apoptosis in MCF-7/adr cells, effects that can be prevented by the JNK inhibitor SP600125 (Item No. 10010466) or protein kinase Cδ (PKCδ) inhibitor rottlerin (Item No. 12006).2WARNING This product is not for human or veterinary use.
References[1] RYAN P. BENNETT . Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase[J]. Antiviral research, 2023, 218: Article 105716. DOI: 10.1016/j.antiviral.2023.105716
[2] SUNG A LEE  Mira J. The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation.[J]. The Journal of Biological Chemistry, 2007: 15271-15283. DOI: 10.1074/jbc.m701362200
7-Deaza-7-carbamoyladenosine hydrate Preparation Products And Raw materials
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