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| | Trimethyl orthoacetate Basic information |
| | Trimethyl orthoacetate Chemical Properties |
| Boiling point | 107-109 °C(lit.) | | density | 0.944 g/mL at 25 °C(lit.) | | vapor pressure | 20 hPa (20 °C) | | refractive index | n20/D 1.388(lit.) | | Fp | 62 °F | | storage temp. | Store below +30°C. | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | form | Liquid | | color | Clear colorless to slightly brown | | Specific Gravity | 0.960 (20/4℃) | | Water Solubility | HYDROLYSIS | | Sensitive | Moisture Sensitive | | BRN | 1098338 | | Henry's Law Constant | 6.4×10-1 mol/(m3Pa) at 25℃, Guthrie (1973) | | InChI | 1S/C5H12O3/c1-5(6-2,7-3)8-4/h1-4H3 | | InChIKey | HDPNBNXLBDFELL-UHFFFAOYSA-N | | SMILES | COC(C)(OC)OC | | LogP | 1.13 at 25℃ | | CAS DataBase Reference | 1445-45-0(CAS DataBase Reference) | | NIST Chemistry Reference | Ethane, 1,1,1-trimethoxy-(1445-45-0) | | EPA Substance Registry System | Trimethyl orthoacetate (1445-45-0) |
| Hazard Codes | F,Xi | | Risk Statements | 11-43-38-36/37/38 | | Safety Statements | 16-37/39-24-33-26-7/9 | | RIDADR | UN 3272 3/PG 2 | | WGK Germany | 1 | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29159080 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 2
Skin Sens. 1B | | Toxicity | LD50 orally in Rabbit: > 2000 mg/kg |
| | Trimethyl orthoacetate Usage And Synthesis |
| Chemical Properties | CLEAR COLOURLESS TO SLIGHTLY BROWN LIQUID | | Uses | Trimethyl orthoacetate has been used in the preparation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alkoxycarbonyloxybut -1-yl)purines. | | General Description | Kinetics and mechanism of gas-phase elimination of trimethyl orthoacetate has been examined over the temperature range of 310-369°C and pressure range of 50-130Torr. | | Toxics Screening Level | The ITSL of Trimethyl orthoacetate is 24 μg/m3 with annual averaging. |
| | Trimethyl orthoacetate Preparation Products And Raw materials |
| Raw materials | Sodium Methoxide-->Ethane, (dimethoxymethoxy)--->1-ethoxy-1,1-dimethoxyethane-->METHYL ACETIMIDATE HYDROCHLORIDE-->1,1-DICHLORO-1-NITROETHANE-->1,1-DIMETHOXYETHENE-->Ethane, 1,1'-[(methoxymethylene)bis(oxy)]bis--->trans-Methyl crotonate | | Preparation Products | 4,6-Dimethylpyrimidine-5-carboxylic acid-->Triethyl orthoacetate-->Methyl 3,3-dimethylpent-4-enoate-->Methyl N-cyanoethanimideate-->N-TERT-BUTYLACETAMIDE-->METHYL 2-CHLORO-3-NITROBENZOATE-->Methyl 2,6-dimethoxybenzoate-->EthaniMidaMide, N,N'-bis(1-Methylethyl)--->DODECYL ACETATE-->N-Isopropylacetamide-->Ganciclovir Mono-O-acetate |
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