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| | 2-Amino-4-chlorophenol Basic information |
| | 2-Amino-4-chlorophenol Chemical Properties |
| Melting point | 136-141 °C(lit.) | | Boiling point | 185.5°C (rough estimate) | | density | 1.2028 (rough estimate) | | refractive index | 1.5618 (estimate) | | storage temp. | 2-8°C | | solubility | 2.3g/l | | pka | 9.31±0.18(Predicted) | | form | Solid | | Colour Index | 76525 | | color | Pale Orange to Light Brown | | Water Solubility | Insoluble. <0.1 g/100 mL at 20 ºC | | BRN | 774859 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | Cosmetics Ingredients Functions | HAIR DYEING | | Cosmetic Ingredient Review (CIR) | 2-Amino-4-chlorophenol (95-85-2) | | InChI | 1S/C6H6ClNO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H,8H2 | | InChIKey | SWFNPENEBHAHEB-UHFFFAOYSA-N | | SMILES | Nc1cc(Cl)ccc1O | | CAS DataBase Reference | 95-85-2(CAS DataBase Reference) | | NIST Chemistry Reference | 5-Chloro-2-hydroxyaniline(95-85-2) | | IARC | 2B (Vol. 123) 2020 | | EPA Substance Registry System | 2-Amino-4-chlorophenol (95-85-2) |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38-20/21/22 | | Safety Statements | 26-36-36/37/39 | | RIDADR | UN 2673 6.1/PG 2 | | WGK Germany | 3 | | RTECS | SJ5700000 | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29222900 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 4 Oral
Carc. 2 |
| | 2-Amino-4-chlorophenol Usage And Synthesis |
| Chemical Properties | 2-Amino-4-chlorophenol is a grayish to light brown crystalline solid or powder | | Uses | Intermediate. | | Uses | 2-Amino-4-chlorophenol is a widely used reagent in the synthesis of various drugs, dyes and pesticides. A reagent in the synthesis of aggrecanase-2 inhibitors based on acylthiosemicarbazide zinc-binding, used in the treatment of osteoarthritis. | | General Description | 5-Chloro-2-hydroxyaniline is a light brown colored crystalline solid. 5-Chloro-2-hydroxyaniline may be toxic by ingestion. 5-Chloro-2-hydroxyaniline is insoluble in water. 5-Chloro-2-hydroxyaniline is used to make other chemicals. | | Air & Water Reactions | 5-Chloro-2-hydroxyaniline may be sensitive to prolonged exposure to air and/or light. Insoluble in water. | | Reactivity Profile | 5-Chloro-2-hydroxyaniline may react with strong oxidizing agents. | | Health Hazard | Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | | Fire Hazard | Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. | | Safety Profile | A poison. Moderately
toxic by ingestion. Mutation data reported.
When heated to decomposition it emits very
toxic fumes of Cland NOx. See also
AROMATIC MINES and CHLORIDES. | | Potential Exposure | Used as a chemical raw material, especially in dye manufacture | | Shipping | UN2673 2-Amino-4-chlorophenol, Hazard Class: 6.1; Labels: 6.1-Poisonous materials | | Incompatibilities | Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, iron, moisture and temperatures .43 C. |
| | 2-Amino-4-chlorophenol Preparation Products And Raw materials |
| Raw materials | 4-CHLORO-2-NITROPHENOL-->chloroazobenzene | | Preparation Products | Neutral Red 2gl-->1-Phenyltetrazole-5-thiol-->(R)-5-chloro-2-(5-Methyl-1,4-diazepan-1-yl)benzo[d]oxazole-->2-Amino-4-chlorophenol-6-sulfonic acid-->3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2(3H)-benzoxazolone-->2,5-Dichlorobenzooxazole-->Acid Black 181-->Mordant Blue 13-->Chromate,bis[4-[[3-[(5-chloro-2-hydroxyphenyl)azo]-2,4-dihydroxyphenyl]azo]-3-hydroxy-7-nitro-1-naphthalenesulfonato]-,disodium hydrogen-->Mordant Black 56-->Mordant Blue 18-->Chromate(1-), [5-[[5-chloro-2-(hydroxy-κO)phenyl]azo-κN1]-4-hydroxy-6-(hydroxy-κO)-2-naphthalenesulfonato(3-)]hydroxy-, sodium-->Mordant Green 28-->Neutral Red 2gl-->Solvent Red 243-->Solvent Violet 58-->Mordant violet 40 (C.I. 14745)-->Acid Black 102 |
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