[2H8]-Bendamustine Hydrochloride

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[2H8]-Bendamustine Hydrochloride Basic information
Product Name:[2H8]-Bendamustine Hydrochloride
Synonyms:[2H8]-Bendamustine Hydrochloride;[2H8]-Bendamustine hydrochloride salt;Bendamustine-d8 HCl;Bendamustine hydrochloride salt;Bendamustine-[D8] Hydrochloride (Standard)
CAS:1185068-23-8
MF:C16H22Cl3N3O2
MW:394.72
EINECS:
Product Categories:
Mol File:1185068-23-8.mol
[2H8]-Bendamustine Hydrochloride Structure
[2H8]-Bendamustine Hydrochloride Chemical Properties
Safety Information
MSDS Information
[2H8]-Bendamustine Hydrochloride Usage And Synthesis
UsesBendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].
References[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17. DOI:10.1158/1078-0432.CCR-07-1061
[3] Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17. DOI:10.1016/j.cellsig.2013.01.020
[4] Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167(4):881-91. DOI:10.1111/j.1476-5381.2012.02048.x
[2H8]-Bendamustine Hydrochloride Preparation Products And Raw materials
Tag:[2H8]-Bendamustine Hydrochloride(1185068-23-8) Related Product Information
5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid 1-Methylethyl Ester 4-[-((-((4-(5-(Bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoyl)oxy)ethyl)(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanic Acid N1-Methylbenzene-1,2,4-triaMine Bendamustine Deschloro Dimer Impurity 5-[Bis(2-chloroethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Methyl Ester 5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Ethyl Ester Bendamustine Related Impurity 9 Bendamustine Related Impurity 22 BendaMustine DiMer 2'-Allyl Ester Bendamustine o-mannitol Ester Bendamustine-D-Mannose Adduct Bendamustine Related Impurity 3 Bendamustine Related Impurity 12 Bendamustine Related Impurity 8 Bendamustine Related Impurity 21 Bendamustine Related Impurity 19 Bendamustine Related Impurity 6 (Mixture of Isomers) BendaMustine Dideschloroethyl