| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
DB1976 hydrochloride manufacturers
|
| | DB1976 hydrochloride Basic information |
| Product Name: | DB1976 hydrochloride | | Synonyms: | DB1976 hydrochloride;DB1976 dihydrochloride;DB1976 dihydrochloride,DB-1976 dihydrochloride;2,2'-(Selenophene-2,5-diyl)bis(1H-benzo[d]imidazole-6-carboximidamide) dihydrochloride;2,2'-(Selenophene-2,5-diyl)bis(1H-benzo[d]imidazole-6-carboximidamide) dihydrochloride;DB1976 2HCl | | CAS: | 2369663-93-2 | | MF: | C20H17ClN8Se | | MW: | 483.83 | | EINECS: | | | Product Categories: | | | Mol File: | 2369663-93-2.mol |  |
| | DB1976 hydrochloride Chemical Properties |
| form | Solid | | color | Brown to black |
| | DB1976 hydrochloride Usage And Synthesis |
| Description | DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding and strongly inhibits the PU.1/DNA complex in vitro. DB1976 has apoptosis-inducing effect. | | Uses | DB1976 dihydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 dihydrochloride potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 dihydrochloride has apoptosis-inducing effect[1][2][3]. | | References | [1] Munde M, et al. Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res. 2014 Jan;42(2):1379-90. DOI:10.1093/nar/gkt955
[2] Stephens DC, et al. Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis. Nucleic Acids Res. 2016 May 19;44(9):4005-13. DOI:10.1093/nar/gkw229
[3] Antony-Debré I, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127(12):4297-4313. DOI:10.1172/JCI92504 |
| | DB1976 hydrochloride Preparation Products And Raw materials |
|