| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
|
| | hDHODH-IN-2 Basic information |
| Product Name: | hDHODH-IN-2 | | Synonyms: | hDHODH-IN-2;2-Propenamide, N-[1,1'-biphenyl]-4-yl-2-cyano-3-cyclopropyl-3-hydroxy- | | CAS: | 183946-00-1 | | MF: | C19H16N2O2 | | MW: | 304.34 | | EINECS: | | | Product Categories: | | | Mol File: | 183946-00-1.mol |  |
| | hDHODH-IN-2 Chemical Properties |
| Boiling point | 545.0±50.0 °C(Predicted) | | density | 1.318±0.06 g/cm3(Predicted) | | pka | 5.23±0.20(Predicted) |
| | hDHODH-IN-2 Usage And Synthesis |
| Uses | hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2]. | | References | [1] Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93. DOI:10.3390/ijms12052982
[2] Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960. DOI:10.1371/journal.pone.0087960 |
| | hDHODH-IN-2 Preparation Products And Raw materials |
|