| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Email: |
3003867561@qq.com |
| Products Intro: |
Product Name:BI-1230
CAS:849022-32-8
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:BI-1230
CAS:849022-32-8
Package:25mg/RMB 10600
|
|
| | BI-1230 Basic information |
| Product Name: | BI-1230 | | Synonyms: | BI-1230;Cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxylic acid, 6-[[(cyclopentyloxy)carbonyl]amino]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[2-[(2-methyl-1-oxopropyl)amino]-4-thiazolyl]-4-quinolinyl]oxy]-5,16-dioxo-, (2R,6S,12Z,13aS,14aR,16aS)- | | CAS: | 849022-32-8 | | MF: | C42H52N6O9S | | MW: | 816.96 | | EINECS: | | | Product Categories: | | | Mol File: | 849022-32-8.mol |  |
| | BI-1230 Chemical Properties |
| density | 1.38±0.1 g/cm3(Predicted) | | pka | 3.32±0.60(Predicted) |
| | BI-1230 Usage And Synthesis |
| Uses | BI-1230 is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity[1]. | | in vivo | BI-1230 (intravenousinjection; 2 mg/kg) shows good PK activity in rat: CL: 15 ml/min/kg, Mean residence time after iv dose: 2.3 hours, Vss: 2.05 L/kg[1].
BI-1230 (oral administation; 5 mg/kg) shows good PK activity in rat: T1/2: 2.1 hours; Tmax: 1.8 nM; Cmax: 405 nM; AUC0-inf: 2550 nM*h; F: 42%[1]. | | References | [1] Overview for BI-1230 an inhibitor of HCV NS3 |
| | BI-1230 Preparation Products And Raw materials |
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