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| | RG7440-NH2 Basic information |
| Product Name: | RG7440-NH2 | | Synonyms: | GDC-0068-NH2;Ipatasertib-NH2;RG7440-NH2;1-Propanone, 3-amino-2-(4-chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-, (2S)- | | CAS: | 1001382-14-4 | | MF: | C21H26ClN5O2 | | MW: | 415.92 | | EINECS: | | | Product Categories: | | | Mol File: | 1001382-14-4.mol |  |
| | RG7440-NH2 Chemical Properties |
| Boiling point | 660.3±55.0 °C(Predicted) | | density | 1.341±0.06 g/cm3(Predicted) | | solubility | DMSO : 210 mg/mL (504.90 mM; Need ultrasonic) | | pka | 13.11±0.40(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | RG7440-NH2 Usage And Synthesis |
| Uses | Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1]. | | Biological Activity | Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | | References | [1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7. |
| | RG7440-NH2 Preparation Products And Raw materials |
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