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| | 6-Trifluoromethoxy-pyridin-3-ylamine Basic information |
| Product Name: | 6-Trifluoromethoxy-pyridin-3-ylamine | | Synonyms: | 3-PyridinaMine, 6-(trifluoroMethoxy)-;3-Amino-6-(trifluoromethoxy)pyridine 95%;6-(trifluoromethoxy)pyridin-3-amine hydrochloride;6-(Trifluoromethoxy)3-pyridinamine;6-TRIFLUOROMETHOXY-PYRIDIN-3-Y;5-Amino-2-(trifluoromethoxy)pyridine;3-Amino-6-(trifluoromethoxy)pyridine;6-(trifluoroMethoxy)pyridin-3-aMine | | CAS: | 135900-33-3 | | MF: | C6H5F3N2O | | MW: | 178.11 | | EINECS: | | | Product Categories: | | | Mol File: | 135900-33-3.mol |  |
| | 6-Trifluoromethoxy-pyridin-3-ylamine Chemical Properties |
| Melting point | 31-33 °C(Solv: cyclohexane (110-82-7)) | | Boiling point | 203.3±35.0 °C(Predicted) | | density | 1.421±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 1.72±0.10(Predicted) | | Appearance | Colorless to light pink <31°C Solid,>33°C Liquid |
| | 6-Trifluoromethoxy-pyridin-3-ylamine Usage And Synthesis |
| Uses | 6-(Trifluoromethoxy)pyridin-3-amine can be used to study synthesis of (Trifluoromethoxy)pyridines. | | Synthesis | General procedure for the synthesis of 6-(trifluoromethoxy)pyridin-3-amine from compound (CAS:1221172-05-9): compound 81 (2.00 g, 9.43 mmol, 1.0 eq.), 10% Pd/C (1.0 g), and ammonium formate (1.2 g, 18.9 mmol, 2.0 eq.) were dissolved in methanol (20 mL) and heated to 55 °C for 16 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered through diatomaceous earth and the filtrate was concentrated to obtain the crude product. The crude product was partitioned between ethyl acetate (100 mL) and 4% NaOH aqueous solution (30 mL) to separate the organic layer. The organic layer was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated to give the target product 82 (1.50 g, 8.38 mmol, 89.4% yield) as a yellow oil. | | References | [1] Patent: WO2016/144792, 2016, A1. Location in patent: Paragraph 00537
[2] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 49
[3] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066 |
| | 6-Trifluoromethoxy-pyridin-3-ylamine Preparation Products And Raw materials |
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