Eliapixant manufacturers
- Eliapixant
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- $135.00 / 1mg
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2024-11-19
- CAS:1948229-21-7
- Min. Order:
- Purity: 98.65%
- Supply Ability: 10g
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| | Eliapixant Basic information |
| Product Name: | Eliapixant | | Synonyms: | Benzamide, 3-(5-methyl-2-thiazolyl)-5-[[(3R)-tetrahydro-3-furanyl]oxy]-N-[(1R)-1-[2-(trifluoromethyl)-5-pyrimidinyl]ethyl]-;BAY 1817080;Eliapixant;Eliapixant（BAY 1817080）;Inhibitor,chronic,Eliapixant,cough,refractory,BAY-1817080,P2X Receptor,BAY1817080,P2X3,inhibit,P2XRs;Eliapixant, 10 mM in DMSO;3-(5-Methylthiazol-2-yl)-5-(((R)-tetrahydrofuran-3-yl)oxy)-N-((R)-1-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)benzamide | | CAS: | 1948229-21-7 | | MF: | C22H21F3N4O3S | | MW: | 478.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1948229-21-7.mol |  |
| | Eliapixant Chemical Properties |
| density | 1.360±0.06 g/cm3(Predicted) | | form | Solid | | pka | 13.02±0.46(Predicted) | | color | White to off-white |
| | Eliapixant Usage And Synthesis |
| Uses | Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough[1][2]. | | in vivo | Eliapixant can be used for the research of coughs and diabetes complications[1]. | | IC 50 | P2X3 Receptor | | References | [1] Spinaci A, et, al. P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications. Front Pharmacol. 2021 Apr 13;12:653561. DOI:10.3389/fphar.2021.653561
[2] Morice A, et, al. Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240. DOI:10.1183/13993003.04240-2020 |
| | Eliapixant Preparation Products And Raw materials |
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