2426685-25-6
| 中文名称 | 2426685-25-6 |
|---|---|
| 中文同义词 | 有效抑制剂多肽TPP-1 |
| 英文名称 | L-Lysine, L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl- |
| 英文同义词 | L-Lysine, L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl- |
| CAS号 | 2426685-25-6 |
| 分子式 | C107H150N34O32S2 |
| 分子量 | 2488.7 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2426685-25-6.mol |
| 结构式 |  |
2426685-25-6 性质
| 密度 | 1.60±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The K D value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1.TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation.
TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors.
| Animal Model: | 5 to 6-week-old female Balb/c nude mice injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector |
| Dosage: | 4 mg/kg |
| Administration: | Subcutaneous injection; 4 mg/kg; every other day eight times; 32days |
| Result: | Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function. |