2-8-Angiotensin II, 2-glycine-5-L-isoleucine-

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2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Basic information
Product Name:2-8-Angiotensin II, 2-glycine-5-L-isoleucine-
Synonyms:2-8-Angiotensin II, 2-glycine-5-L-isoleucine-;TRV055;2-8-Angiotensin II
CAS:25849-90-5
MF:C42H57N9O9
MW:831.97
EINECS:
Product Categories:
Mol File:25849-90-5.mol
2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Structure
2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Chemical Properties
Boiling point 1273.8±65.0 °C(Predicted)
density 1.296±0.06 g/cm3(Predicted)
form Solid
pka3.56±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Usage And Synthesis
UsesTRV055, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling[1].
IC 50AT1 Receptor
References[1] Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11. DOI:10.1016/j.cell.2018.12.005
2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Preparation Products And Raw materials
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