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ChemeGen |
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18818260767 |
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9(10H)-Acridinone, 2-methoxy-5,6-dimethyl- manufacturers
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| | 9(10H)-Acridinone, 2-methoxy-5,6-dimethyl- Basic information |
| | 9(10H)-Acridinone, 2-methoxy-5,6-dimethyl- Chemical Properties |
| Boiling point | 445.2±45.0 °C(Predicted) | | density | 1.177±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 1 mg/ml,DMSO: 1 mg/ml | | form | A crystalline solid | | pka | 0.53±0.50(Predicted) |
| | 9(10H)-Acridinone, 2-methoxy-5,6-dimethyl- Usage And Synthesis |
| Uses | STING agonist-14 (compound 12b) is a potent STING agonist that is efficacious across species. STING agonist-14 could activate the pathway by directly binding human STING. STING agonist-14 can be used for the research of tumours or viral infections[1]. | | Biological Activity | STING agonist 12b is an agonist of stimulator of interferon genes (STING).1 It binds to STING (Kd = 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. | | References | 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020) |
| | 9(10H)-Acridinone, 2-methoxy-5,6-dimethyl- Preparation Products And Raw materials |
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