Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-

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Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- Suppliers list
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Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- Basic information
Product Name:Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-
Synonyms:Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-;CDK6/9-IN-1
CAS:2414373-55-8
MF:C22H25ClN8O
MW:452.94
EINECS:
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Mol File:2414373-55-8.mol
Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- Structure
Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- Chemical Properties
density 1.374±0.06 g/cm3(Predicted)
pka14.70±0.70(Predicted)
Safety Information
MSDS Information
Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- Usage And Synthesis
UsesCDK6/9-IN-1 (compound 66) is an orally active active and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively[1].
in vivo

CDK6/9-IN-1 (compound 66) significantly inhibits tumor growth in an xenograft mouse model with no obvious toxicity, indicating the promising therapeutic potential of CDK6/9 dual inhibitors for cancer treatment[1].

IC 50CDK6: 40.5 nM (IC50); CDK9: 39.5 nM (IC50)
References[1] Yang Wang, et al. Discovery and SARs of 5-Chloro- N4-phenyl- N2-(pyridin-2-yl)pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors With Potent Antitumor Activity. J Med Chem. 2020 Mar 26;63(6):3327-3347. DOI:10.1021/acs.jmedchem.9b02121
Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- Preparation Products And Raw materials
Tag:Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-(2414373-55-8) Related Product Information
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